PMID- 7689820
OWN - NLM
STAT- MEDLINE
DCOM- 19930930
LR  - 20121115
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 34
IP  - 3
DP  - 1993 Sep
TI  - The T-cell response to myelin basic protein in familial multiple sclerosis: 
      diversity of fine specificity, restricting elements, and T-cell receptor usage.
PG  - 385-93
AB  - Indirect evidence suggests that an autoimmune response to myelin basic protein 
      (MBP) may be involved in the pathogenesis of multiple sclerosis (MS). In MS, 
      several reports have suggested that restricted T-cell populations respond to MPB, 
      as in inbred rodents with the MS disease model experimental allergic 
      encephalomyelitis. In experimental allergic encephalomyelitis, the T-cell 
      repertoire to MBP varies between strains, and in MS it is likely that the 
      response to MBP is also best defined under conditions where genetic differences 
      between subjects are controlled. In this report, the fine specificity of the 
      T-cell response to MBP was assessed in three families, each with multiple 
      individuals affected with MS. We found that (1) comparable frequencies of 
      MBP-reactive T-cell lines were obtained from peripheral blood of MS patients and 
      their healthy siblings. Human leukocyte antigen (HLA) identical sibling pairs 
      discordant for MS had similar frequencies of MBP-reactive T-cell lines. (2) A 
      broad spectrum of MBP epitopes was recognized by T-cell lines from all 
      individuals studied. Within a family, the fine specificity of MBP recognition 
      showed little or no overlap between individuals, even between HLA identical 
      siblings. (3) Recognition of MBP epitopes occurred in the context of different 
      HLA class II alleles. At least four DR alleles each served as restricting 
      elements for recognition of P82-101 or the carboxy terminal region of MBP, two 
      regions thought to be important in the human T-cell response to the molecule. No 
      relationship between the use of a particular DR allele and a response to a 
      particular region of MBP could be established.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Joshi, N
AU  - Joshi N
AD  - Department of Neurology, University of California at San Francisco 94143-0114.
FAU - Usuku, K
AU  - Usuku K
FAU - Hauser, S L
AU  - Hauser SL
LA  - eng
GR  - NS26799/NS/NINDS NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (HLA-D Antigens)
RN  - 0 (Myelin Basic Protein)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Alleles
MH  - Cell Line
MH  - Cells, Cultured
MH  - Female
MH  - HLA-D Antigens/*analysis
MH  - Haplotypes
MH  - Humans
MH  - Major Histocompatibility Complex
MH  - Male
MH  - Multiple Sclerosis/*genetics/*immunology
MH  - Myelin Basic Protein/*immunology
MH  - Pedigree
MH  - Receptors, Antigen, T-Cell/*immunology
MH  - T-Lymphocytes/*immunology
EDAT- 1993/09/01 00:00
MHDA- 1993/09/01 00:01
CRDT- 1993/09/01 00:00
PHST- 1993/09/01 00:00 [pubmed]
PHST- 1993/09/01 00:01 [medline]
PHST- 1993/09/01 00:00 [entrez]
AID - 10.1002/ana.410340313 [doi]
PST - ppublish
SO  - Ann Neurol. 1993 Sep;34(3):385-93. doi: 10.1002/ana.410340313.