PMID- 7691108
OWN - NLM
STAT- MEDLINE
DCOM- 19931026
LR  - 20071114
IS  - 1044-1549 (Print)
IS  - 1044-1549 (Linking)
VI  - 9
IP  - 3
DP  - 1993 Sep
TI  - Expression of monocyte chemoattractant protein-1 (MCP-1) by rat alveolar 
      macrophages during chronic lung injury.
PG  - 300-5
AB  - Using a well-characterized model of bleomycin-induced pulmonary fibrosis in the 
      rat, we determined that there was a time-dependent elaboration of monocyte 
      chemotactic activity in bronchoalveolar lavage fluid. Northern hybridization 
      analysis revealed markedly increased expression of rat monocyte chemoattractant 
      protein-1 (MCP-1) mRNA in alveolar macrophages (AMs) from rats following 
      induction of pulmonary fibrosis. Monocyte chemotactic activity was also 
      significantly increased in conditioned media from AMs retrieved from injured rat 
      lungs. These data suggest that one important role of AMs in the pathogenesis of 
      chronic inflammatory lung injury and pulmonary fibrosis is the regulation of 
      monocyte recruitment and activation within the lung secondary to secretion of 
      monocyte chemoattractants including MCP-1.
FAU - Brieland, J K
AU  - Brieland JK
AD  - Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann 
      Arbor 48109-0614.
FAU - Jones, M L
AU  - Jones ML
FAU - Flory, C M
AU  - Flory CM
FAU - Miller, G R
AU  - Miller GR
FAU - Warren, J S
AU  - Warren JS
FAU - Phan, S H
AU  - Phan SH
FAU - Fantone, J C
AU  - Fantone JC
LA  - eng
GR  - HL-07517/HL/NHLBI NIH HHS/United States
GR  - HL-40526/HL/NHLBI NIH HHS/United States
GR  - HL-48287/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Respir Cell Mol Biol
JT  - American journal of respiratory cell and molecular biology
JID - 8917225
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Cytokines)
RN  - 11056-06-7 (Bleomycin)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Bleomycin
MH  - Blotting, Northern
MH  - Chemokine CCL2
MH  - Chemotactic Factors/*biosynthesis
MH  - Chemotaxis
MH  - Cytokines/*biosynthesis
MH  - DNA
MH  - Lung/*pathology
MH  - Macrophages, Alveolar/*metabolism
MH  - Male
MH  - Molecular Sequence Data
MH  - Pulmonary Fibrosis/immunology/*metabolism
MH  - Rats
MH  - Rats, Inbred F344
EDAT- 1993/09/01 00:00
MHDA- 1993/09/01 00:01
CRDT- 1993/09/01 00:00
PHST- 1993/09/01 00:00 [pubmed]
PHST- 1993/09/01 00:01 [medline]
PHST- 1993/09/01 00:00 [entrez]
AID - 10.1165/ajrcmb/9.3.300 [doi]
PST - ppublish
SO  - Am J Respir Cell Mol Biol. 1993 Sep;9(3):300-5. doi: 10.1165/ajrcmb/9.3.300.