PMID- 7691564
OWN - NLM
STAT- MEDLINE
DCOM- 19931109
LR  - 20190721
IS  - 0013-4694 (Print)
IS  - 0013-4694 (Linking)
VI  - 88
IP  - 5
DP  - 1993 Sep-Oct
TI  - Electroencephalogram and evoked potentials in the primate model of viral 
      encephalitis.
PG  - 397-407
AB  - Squirrel monkeys with induced canine distemper virus (CDV) encephalitis showed 
      characteristic clinical signs such as seizures or myoclonus, with EEGs showing 
      periodic synchronized discharge (PSD). Histopathologically, there was gliosis and 
      neuronal degeneration diffusely distributed in both the gray and white matters in 
      the subacute phase, the lesions resembling those found in childhood acute viral 
      encephalitis and subacute sclerosing panencephalitis (SSPE). The auditory 
      brain-stem response (ABR) changes were remarkable in the subacute phase, and the 
      recovery of latency was correlated with survival. The visual evoked potential 
      (VEP) abnormalities disappeared in the acute phase and appeared again with 
      delayed latency in the subacute stage. One monkey which did not show clinical 
      signs but had the pathological changes showed the VEP abnormality. These data 
      suggest that the evoked potentials are helpful in judging the prognosis, and that 
      this model is useful for the analysis of the pathogenesis of viral encephalitis.
FAU - Ochikubo, F
AU  - Ochikubo F
AD  - Corporation for Production and Research of Laboratory Primates, Ibaraki, Japan.
FAU - Nagata, T
AU  - Nagata T
FAU - Yoshikawa, Y
AU  - Yoshikawa Y
FAU - Matsubara, Y
AU  - Matsubara Y
FAU - Kai, C
AU  - Kai C
FAU - Yamanouchi, Y
AU  - Yamanouchi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Electroencephalogr Clin Neurophysiol
JT  - Electroencephalography and clinical neurophysiology
JID - 0375035
SB  - IM
MH  - Animals
MH  - Brain/pathology/*physiopathology
MH  - Disease Models, Animal
MH  - Distemper/*physiopathology
MH  - Electroencephalography
MH  - Encephalitis/microbiology/*physiopathology
MH  - Evoked Potentials/physiology
MH  - Evoked Potentials, Auditory, Brain Stem
MH  - Evoked Potentials, Visual
MH  - Male
MH  - Reaction Time/physiology
MH  - Saimiri
EDAT- 1993/09/01 00:00
MHDA- 1993/09/01 00:01
CRDT- 1993/09/01 00:00
PHST- 1993/09/01 00:00 [pubmed]
PHST- 1993/09/01 00:01 [medline]
PHST- 1993/09/01 00:00 [entrez]
AID - 10.1016/0168-5597(93)90016-i [doi]
PST - ppublish
SO  - Electroencephalogr Clin Neurophysiol. 1993 Sep-Oct;88(5):397-407. doi: 
      10.1016/0168-5597(93)90016-i.