PMID- 7692038
OWN - NLM
STAT- MEDLINE
DCOM- 19931104
LR  - 20200220
IS  - 0894-9255 (Print)
IS  - 0894-9255 (Linking)
VI  - 6
IP  - 10
DP  - 1993 Oct
TI  - Mother-to-child transmission of human T-cell lymphotropic virus type I (HTLV-I) 
      in Jamaica: association with antibodies to envelope glycoprotein (gp46) epitopes.
PG  - 1162-7
AB  - To study mother-to-child transmission of HTLV-I in Jamaica, we screened antenatal 
      patients in Kingston, Jamaica, from 1983 to 1985. Of 2,329 women, 81 (3.5%) were 
      HTLV-I seropositive. Two to three years later, 36 seropositive mothers were 
      recontacted, and blood was drawn from them and their children. All sera were 
      tested for HTLV-I antibodies, and mother's sera were additionally tested for 
      HTLV-I whole-virus antibody titer, syncytium-inhibition neutralizing antibody 
      titer, and titers to six synthetic peptides from the HTLV-I envelope glycoprotein 
      gp46. Seventeen of 74 (23%) [95% confidence interval (CI) 15-34%] children were 
      seropositive. HTLV-I transmission was associated with breast-feeding duration > 6 
      months [relative risk (RR) 3.2; CI 0.4-22.1], maternal age > 30 years (RR 2.8; CI 
      1.0-7.8), and higher maternal whole-virus antibody titer (RR 3.3; CI 1.3-8.5). 
      After controlling for higher whole-virus antibody titer, transmission remained 
      associated with higher titer of neutralizing antibody and higher titer of 
      antibody to the peptide sp4a1, corresponding to amino acids 196-209 of the gp46 
      envelope glycoprotein. We conclude that mother-to-child transmission of HTLV-I in 
      Jamaica is associated with longer duration of breast-feeding, older age, and 
      higher HTLV-I antibody titer, in particular to a certain immunogenic portion of 
      the gp46 envelope glycoprotein.
FAU - Wiktor, S Z
AU  - Wiktor SZ
AD  - Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland.
FAU - Pate, E J
AU  - Pate EJ
FAU - Murphy, E L
AU  - Murphy EL
FAU - Palker, T J
AU  - Palker TJ
FAU - Champegnie, E
AU  - Champegnie E
FAU - Ramlal, A
AU  - Ramlal A
FAU - Cranston, B
AU  - Cranston B
FAU - Hanchard, B
AU  - Hanchard B
FAU - Blattner, W A
AU  - Blattner WA
LA  - eng
GR  - NCI NO1-CP-31006/CP/NCI NIH HHS/United States
GR  - NCI RO1-CA40660/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Acquir Immune Defic Syndr (1988)
JT  - Journal of acquired immune deficiency syndromes
JID - 8812597
RN  - 0 (Epitopes)
RN  - 0 (Gene Products, env)
RN  - 0 (HTLV-I Antibodies)
RN  - 0 (HTLV-I Antigens)
RN  - 0 (Retroviridae Proteins, Oncogenic)
RN  - 0 (gp46 protein, Human T-cell leukemia virus type I)
SB  - IM
MH  - Adolescent
MH  - Breast Feeding
MH  - Child
MH  - Child, Preschool
MH  - Epitopes/immunology
MH  - Female
MH  - Gene Products, env/*immunology
MH  - HTLV-I Antibodies/*blood
MH  - HTLV-I Antigens/*immunology
MH  - HTLV-I Infections/epidemiology/immunology/*transmission
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Jamaica/epidemiology
MH  - Maternal Age
MH  - Pregnancy
MH  - Retroviridae Proteins, Oncogenic/*immunology
MH  - Risk Factors
EDAT- 1993/10/01 00:00
MHDA- 1993/10/01 00:01
CRDT- 1993/10/01 00:00
PHST- 1993/10/01 00:00 [pubmed]
PHST- 1993/10/01 00:01 [medline]
PHST- 1993/10/01 00:00 [entrez]
PST - ppublish
SO  - J Acquir Immune Defic Syndr (1988). 1993 Oct;6(10):1162-7.