PMID- 7692698
OWN - NLM
STAT- MEDLINE
DCOM- 19931022
LR  - 20181130
IS  - 0001-6772 (Print)
IS  - 0001-6772 (Linking)
VI  - 148
IP  - 3
DP  - 1993 Jul
TI  - The effect of endothelin, neuropeptide Y, calcitonin gene-related peptide and 
      substance P on neutrophil functions.
PG  - 341-6
AB  - Neuropeptides are putative mediators of inflammation. At physiological 
      concentrations substance P has been shown to prime polymorphonuclear neutrophil 
      granulocyte (PMN) chemiluminescence (CL). In the present study we show also that 
      both endothelin and neuropeptide Y (NPY), but not calcitonin gene-related peptide 
      (CGRP) are able to prime PMN oxidative metabolism. At similar nanomolar 
      concentrations SP and endothelin (but not NPY) also primed 
      formyl-methionyl-leucyl-phenylalanine (fMLP)-induced rises of cytosolic calcium. 
      On the other hand, NPY caused a direct and dose-related increase of cytosolic 
      calcium concentrations. None of the mentioned neuropeptides primed PMN 
      aggregation or directly induced CL, aggregation or chemotaxis over a wide range 
      of concentrations (1 fM-1 microM).
FAU - Hafstrom, I
AU  - Hafstrom I
AD  - Department of Rheumatology, Karolinska Institutet, Stockholm Soder Hospital, 
      Sweden.
FAU - Ringertz, B
AU  - Ringertz B
FAU - Lundeberg, T
AU  - Lundeberg T
FAU - Palmblad, J
AU  - Palmblad J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Physiol Scand
JT  - Acta physiologica Scandinavica
JID - 0370362
RN  - 0 (Endothelins)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Neuropeptides)
RN  - 33507-63-0 (Substance P)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
RN  - SY7Q814VUP (Calcium)
RN  - TSN3DL106G (Fura-2)
SB  - IM
MH  - Calcitonin Gene-Related Peptide/pharmacology
MH  - Calcium/metabolism
MH  - Cell Aggregation/drug effects
MH  - Chemotaxis, Leukocyte/drug effects
MH  - Endothelins/pharmacology
MH  - Fura-2
MH  - Humans
MH  - In Vitro Techniques
MH  - Luminescent Measurements
MH  - N-Formylmethionine Leucyl-Phenylalanine/pharmacology
MH  - Neuropeptide Y/pharmacology
MH  - Neuropeptides/*pharmacology
MH  - Neutrophils/*drug effects/metabolism
MH  - Oxidation-Reduction
MH  - Signal Transduction/drug effects
MH  - Substance P/pharmacology
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
AID - 10.1111/j.1748-1716.1993.tb09565.x [doi]
PST - ppublish
SO  - Acta Physiol Scand. 1993 Jul;148(3):341-6. doi: 
      10.1111/j.1748-1716.1993.tb09565.x.