PMID- 7694142
OWN - NLM
STAT- MEDLINE
DCOM- 19931214
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 319
IP  - 3
DP  - 1993 Nov
TI  - Cytogenetic damage induced in human lymphocytes by four vanadium compounds and 
      micronucleus analysis by fluorescence in situ hybridization with a centromeric 
      probe.
PG  - 205-13
AB  - The genotoxicity of four vanadium compounds, sodium metavanadate (NaVO3), 
      ammonium metavanadate (NH4VO3), sodium ortovanadate (Na3VO4) and vanadyl sulfate 
      (SVO5), was evaluated in human lymphocyte cultures using structural and numerical 
      chromosome aberrations, micronuclei, sister-chromatid exchanges and satellite 
      chromosome associations as endpoints. These compounds were not found to increase 
      the frequency of structural chromosome aberrations whereas a significant increase 
      in numerical aberrations, micronuclei and satellite associations was found. Since 
      these results could have been related to a possible mechanism of the action of 
      vanadium as a mitotic spindle poison, the fluorescence in situ hybridization 
      (FISH) technique was applied to the human lymphocyte micronucleus assay, by means 
      of an alphoid centromere-specific DNA probe. The four vanadium salts showed a 
      micronucleus percentage with positive signal (presence of centromere and thus of 
      whole chromosome(s)) that was always higher than 68% at all doses tested. That 
      confirmed the aneuploidogenic potentiality of vanadium.
FAU - Migliore, L
AU  - Migliore L
AD  - Dipartimento di Scienze, Universita di Pisa, Italy.
FAU - Bocciardi, R
AU  - Bocciardi R
FAU - Macri, C
AU  - Macri C
FAU - Lo Jacono, F
AU  - Lo Jacono F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (DNA Probes)
RN  - 0 (Mutagens)
RN  - 0 (Vanadium Compounds)
SB  - IM
MH  - Cells, Cultured
MH  - Centromere
MH  - DNA Probes
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphocytes/drug effects
MH  - Male
MH  - Micronucleus Tests
MH  - Mutagens/*toxicity
MH  - Sister Chromatid Exchange
MH  - Vanadium Compounds/*toxicity
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
AID - 0165-1218(93)90080-W [pii]
AID - 10.1016/0165-1218(93)90080-w [doi]
PST - ppublish
SO  - Mutat Res. 1993 Nov;319(3):205-13. doi: 10.1016/0165-1218(93)90080-w.