PMID- 7694647
OWN - NLM
STAT- MEDLINE
DCOM- 19940104
LR  - 20191023
IS  - 0923-1811 (Print)
IS  - 0923-1811 (Linking)
VI  - 5
IP  - 3
DP  - 1993 Jun
TI  - Elevated serum soluble interleukin-2 receptor levels in subacute cutaneous lupus 
      erythematosus.
PG  - 143-9
AB  - Subacute cutaneous lupus erythematosus (SCLE) is a subset of lupus erythematosus 
      which is characterized by unique cutaneous manifestations and immunological 
      abnormalities. Soluble IL-2 receptor (sIL-2 R) is the shed product of membrane 
      Il-2 R, a product of T cell activation. It is measured by enzyme-linked 
      immunosorbent assay (ELISA) and has been found to correlate well with disease 
      activity in systemic lupus erythematosus (SLE) patients. The objective of the 
      present work was to determine whether there is a correlation between sIL-2 R 
      levels and disease activity in SCLE. Serum samples were obtained from 25 SCLE 
      patients and then measured for sIL-2 R levels of ELISA. Fifteen of 25 SCLE 
      patients tested had normal levels of sIL-2 R, while 10 of 25 SCLE patients had 
      elevated sIL-2 R levels. The serum sIL-2 R level in SCLE patients correlated well 
      with disease activity and the number of American College of Rheumatology criteria 
      for SLE. These findings indicate that sIL-2 R levels can be used as a valuable 
      laboratory parameter in managing SCLE patients.
FAU - Neish, C
AU  - Neish C
AD  - Department of Dermatology, University of Pittsburgh, PA 15240.
FAU - Charley, M
AU  - Charley M
FAU - Fertig, N
AU  - Fertig N
FAU - Medsger, T Jr
AU  - Medsger T Jr
FAU - Deng, J S
AU  - Deng JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Dermatol Sci
JT  - Journal of dermatological science
JID - 9011485
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, Interleukin-2)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Autoantibodies/analysis
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/*blood/immunology
MH  - Precipitin Tests
MH  - RNA/metabolism
MH  - Receptors, Interleukin-2/*metabolism
MH  - Solubility
EDAT- 1993/06/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1993/06/01 00:00
PHST- 1993/06/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1993/06/01 00:00 [entrez]
AID - 0923-1811(93)90761-D [pii]
AID - 10.1016/0923-1811(93)90761-d [doi]
PST - ppublish
SO  - J Dermatol Sci. 1993 Jun;5(3):143-9. doi: 10.1016/0923-1811(93)90761-d.