PMID- 7695743
OWN - NLM
STAT- MEDLINE
DCOM- 19950217
LR  - 20220129
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 23
IP  - 1
DP  - 1994 Sep 1
TI  - Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and 
      beta-adrenergic receptor kinase 2 (ADRBK2) genes.
PG  - 286-8
AB  - Two types of proteins play a major role in determining homologous desensitization 
      of G-coupled receptors: beta-adrenergic receptor kinase (beta ARK), which 
      phosphorylates the agonist-occupied receptor and its functional cofactor, 
      beta-arrestin. Both beta ARK and beta-arrestin are members of multigene families. 
      The family of G-protein-coupled receptor kinases includes rhodopsin kinase, beta 
      ARK1, beta ARK2, IT11-A (GRK4), GRK5, and GRK6. The arrestin/beta-arrestin gene 
      family includes arrestin (also known as S-antigen), beta-arrestin 1, and 
      beta-arrestin 2. Here we report the chromosome mapping of the human genes for 
      arrestin (SAG), beta-arrestin 2 (ARRB2), and beta ARK2 (ADRBK2) by fluorescence 
      in situ hybridization (FISH). FISH results confirmed the assignment of the gene 
      coding for arrestin (SAG) to chromosome 2 and allowed us to refine its 
      localization to band q37. The gene coding for beta-arrestin 2 (ARRB2) was mapped 
      to chromosome 17p13 and that coding for beta ARK2 (ADRBK2) to chromosome 22q11.
FAU - Calabrese, G
AU  - Calabrese G
AD  - Consorzio Mario Negri Sud, Istituto di Ricerche Farmacologiche Mario Negri, Santa 
      Maria Imbaro, Italy.
FAU - Sallese, M
AU  - Sallese M
FAU - Stornaiuolo, A
AU  - Stornaiuolo A
FAU - Stuppia, L
AU  - Stuppia L
FAU - Palka, G
AU  - Palka G
FAU - De Blasi, A
AU  - De Blasi A
LA  - eng
GR  - E.0062/TI_/Telethon/Italy
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (ARRB1 protein, human)
RN  - 0 (ARRB2 protein, human)
RN  - 0 (Antigens)
RN  - 0 (Arrestin)
RN  - 0 (Arrestins)
RN  - 0 (Eye Proteins)
RN  - 0 (beta-Arrestin 1)
RN  - 0 (beta-Arrestin 2)
RN  - 0 (beta-Arrestins)
RN  - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
RN  - EC 2.7.11.15 (G-Protein-Coupled Receptor Kinase 3)
RN  - EC 2.7.11.15 (GRK3 protein, human)
RN  - EC 2.7.11.15 (beta-Adrenergic Receptor Kinases)
SB  - IM
GS  - ADRBK2
GS  - ARRB2
GS  - SAG
MH  - Antigens/*genetics
MH  - Arrestin
MH  - *Arrestins
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 17
MH  - *Chromosomes, Human, Pair 2
MH  - *Chromosomes, Human, Pair 22
MH  - Cyclic AMP-Dependent Protein Kinases/*genetics
MH  - Eye Proteins/*genetics
MH  - G-Protein-Coupled Receptor Kinase 3
MH  - Gene Library
MH  - Genes
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - RNA Splicing
MH  - beta-Adrenergic Receptor Kinases
MH  - beta-Arrestin 1
MH  - beta-Arrestin 2
MH  - beta-Arrestins
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - S0888-7543(84)71497-2 [pii]
AID - 10.1006/geno.1994.1497 [doi]
PST - ppublish
SO  - Genomics. 1994 Sep 1;23(1):286-8. doi: 10.1006/geno.1994.1497.