PMID- 7696024
OWN - NLM
STAT- MEDLINE
DCOM- 19950504
LR  - 20190503
IS  - 0007-0769 (Print)
IS  - 0007-0769 (Linking)
VI  - 73
IP  - 2
DP  - 1995 Feb
TI  - Ergometric exercise testing and sensitivity of cyclic guanosine 
      3',5'-monophosphate (cGMP) in diagnosing asymptomatic left ventricular 
      dysfunction.
PG  - 145-50
AB  - OBJECTIVE: Increased plasma concentrations of cyclic guanosine monophosphate 
      (cGMP) have been reported in patients with manifest heart failure. At rest, 
      however, cGMP concentrations in patients with asymptomatic left ventricular 
      dysfunction or heart failure in New York Heart Association (NYHA) functional 
      class I do not differ significantly from those of healthy subjects. The purpose 
      of this study was to investigate whether graded exercise on an ergometer improves 
      the sensitivity of cGMP in diagnosing asymptomatic left ventricular dysfunction. 
      PATIENTS: Plasma cGMP concentrations were compared in 17 healthy controls and 98 
      patients with asymptomatic left ventricular dysfunction or congestive heart 
      failure of different stages (asymptomatic left ventricular dysfunction or NYHA 
      functional class I, 56 patients; NYHA class II, 31 patients; NYHA class III, 11 
      patients). RESULTS: Before exercise plasma cGMP concentrations in patients with 
      clinical heart failure (NYHA functional classes II and III) were significantly 
      higher than those in healthy controls. In patients with asymptomatic left 
      ventricular dysfunction or heart failure of functional class I plasma cGMP 
      concentrations were not significantly different from those in healthy subjects. 
      Thirty minutes after exercise, however, cGMP concentrations in patients with 
      asymptomatic left ventricular dysfunction or class I heart failure were 
      significantly higher than those in healthy controls. CONCLUSION: Measurement of 
      plasma cGMP concentrations 30 minutes after ergometric exercise testing allows 
      better discrimination between healthy subjects and patients with symptomless left 
      ventricular dysfunction or mild heart failure (NYHA class I) than measurement of 
      such concentrations before exercise.
FAU - Jakob, G
AU  - Jakob G
AD  - Department of Medical Chemistry and Biochemistry, University of Innsbruck Medical 
      School, Austria.
FAU - Mair, J
AU  - Mair J
FAU - Pichler, M
AU  - Pichler M
FAU - Puschendorf, B
AU  - Puschendorf B
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br Heart J
JT  - British heart journal
JID - 0370634
RN  - 0 (Biomarkers)
RN  - H2D2X058MU (Cyclic GMP)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Cyclic GMP/*blood
MH  - Exercise Test
MH  - Female
MH  - Heart Failure/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Time Factors
MH  - Ventricular Dysfunction, Left/blood/*diagnosis
PMC - PMC483781
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
PMCR- 1995/02/01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
PHST- 1995/02/01 00:00 [pmc-release]
AID - 10.1136/hrt.73.2.145 [doi]
PST - ppublish
SO  - Br Heart J. 1995 Feb;73(2):145-50. doi: 10.1136/hrt.73.2.145.