PMID- 7696628
OWN - NLM
STAT- MEDLINE
DCOM- 19950504
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 5
IP  - 18
DP  - 1994 Dec 20
TI  - Spinal serotonin IA and IC/2 receptors mediate supraspinal mu opioid-induced 
      analgesia.
PG  - 2665-8
AB  - Intracerebroventricular (i.c.v.) injection of highly selective mu opioid receptor 
      agonist ohmefentanyl (OMF) to rats produced dose-dependent antinociception as 
      assessed with the tail flick test. This analgesia could be blocked by intrathecal 
      (i.t.) injection of the 5-HT1A receptor antagonist spiperone or the 5-HT1C/2 
      receptor antagonist mianserin, but not by the 5-HT2 receptor antagonist 1-NP or 
      the 5-HT3 receptor antagonist ICS 205-930. The results suggest that the 
      descending 5-HT system is involved in mediating spinal mu opioid analgesia via 
      spinal 5-HT1A and 5-HT1C/2 receptors.
FAU - Xu, W
AU  - Xu W
AD  - Neuroscience Research Center, Beijing Medical University, China.
FAU - Cui, X
AU  - Cui X
FAU - Han, J S
AU  - Han JS
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Receptors, Opioid, mu)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Serotonin Antagonists)
RN  - 78995-14-9 (F 7302)
RN  - UF599785JZ (Fentanyl)
SB  - IM
MH  - *Analgesia
MH  - Animals
MH  - Brain/*physiology
MH  - Fentanyl/analogs & derivatives/pharmacology
MH  - Injections, Intraventricular
MH  - Injections, Spinal
MH  - Male
MH  - Pain Threshold/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Reaction Time
MH  - Receptors, Opioid, mu/*agonists
MH  - Receptors, Serotonin/classification/*physiology
MH  - Serotonin Antagonists/pharmacology
MH  - Spinal Cord/*metabolism
EDAT- 1994/12/20 00:00
MHDA- 1994/12/20 00:01
CRDT- 1994/12/20 00:00
PHST- 1994/12/20 00:00 [pubmed]
PHST- 1994/12/20 00:01 [medline]
PHST- 1994/12/20 00:00 [entrez]
AID - 10.1097/00001756-199412000-00065 [doi]
PST - ppublish
SO  - Neuroreport. 1994 Dec 20;5(18):2665-8. doi: 10.1097/00001756-199412000-00065.