PMID- 7697634
OWN - NLM
STAT- MEDLINE
DCOM- 19950428
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 80
IP  - 1
DP  - 1995 Mar
TI  - Detection of M-bcr/abl fusion by fluorescence in situ hybridization (FISH) in a 
      case of Ph negative CML.
PG  - 60-2
AB  - A balanced reciprocal translocation, t(6;9)(p21;q34), was identified in a female 
      patient diagnosed with chronic myeloid leukemia (CML). Both homologs of 
      chromosome 22 were of normal length and morphology. Southern blotting revealed a 
      bcr rearrangement with BglII and HindIII. Two signals for the abl probe were 
      demonstrated by fluorescence in situ hybridization (FISH), one on the normal 
      chromosome 9 and the second on a chromosome 22. Thus, molecular rearrangement of 
      bcr resulted from insertion of an abl gene within the bcr region despite absence 
      of a Ph chromosome.
FAU - Mohamed, A N
AU  - Mohamed AN
AD  - Pathology Department/Harper Hospital, Wayne State University, Detroit, Michigan 
      48201, USA.
FAU - Ebrahim, S A
AU  - Ebrahim SA
FAU - Sarkar, F H
AU  - Sarkar FH
FAU - Uberti, J
AU  - Uberti J
FAU - Wolman, S R
AU  - Wolman SR
LA  - eng
GR  - 5-P30CA-22453/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - *Chromosomes, Human, Pair 6
MH  - *Chromosomes, Human, Pair 9
MH  - Female
MH  - Fusion Proteins, bcr-abl/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative/*genetics
MH  - Middle Aged
MH  - *Translocation, Genetic
EDAT- 1995/03/01 00:00
MHDA- 1995/03/01 00:01
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 1995/03/01 00:01 [medline]
PHST- 1995/03/01 00:00 [entrez]
AID - 016546089400118U [pii]
AID - 10.1016/0165-4608(94)00118-u [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1995 Mar;80(1):60-2. doi: 10.1016/0165-4608(94)00118-u.