PMID- 7699115
OWN - NLM
STAT- MEDLINE
DCOM- 19950504
LR  - 20190909
IS  - 0303-6987 (Print)
IS  - 0303-6987 (Linking)
VI  - 21
IP  - 6
DP  - 1994 Dec
TI  - Prognostic significance of nucleolar organizer regions (NORS) in malignant 
      melanoma.
PG  - 494-9
AB  - Nucleolar organizer regions (NORs) are loops of ribosomal DNA (rDNA) in the 
      nucleolus and are associated with acidic proteins. They are seen in routinely 
      processed paraffin sections by using a one-step colloidal silver (Ag) staining 
      method; they appear as black dots termed "AgNORs". The quantitative assay of 
      AgNORs has been used to differentiate benign from malignant neoplasms. 
      Melanocytic lesions differ significantly in AgNOR counts between malignant 
      melanoma and nevi. However, conflicting results have been reported as to AgNORs' 
      prognostic value in melanoma. A recent study showed AgNOR counts to be a more 
      accurate prognostic indicator than Breslow's thickness. In this study, we counted 
      the AgNORs in 26 patients with primary cutaneous melanomas (CMM) between 2.0 mm 
      and 2.5 mm thick. Of these, 14 are alive without disease (AN) at 5 years after 
      diagnosis (group 1) and 12 are dead of disease (DD) in less than 5 years (group 
      2). The AgNORs were scored in 30 nuclei per tumor, and the means were calculated. 
      For group 1, the mean number of AgNORs per nucleus was 6.88, ranging from 3.73 to 
      12.70. For group 2, the mean number was 6.97, ranging from 3.63 to 11.67. 
      Statistical analysis using analysis of variance (ANOVA) showed no significant 
      difference between the groups (p = 0.33). In our study, AgNOR counts did not 
      prove to be of prognostic value in malignant melanoma.
FAU - Ronan, S G
AU  - Ronan SG
AD  - Department of Pathology, University of Illinois at Chicago 60612.
FAU - Farolan, M J
AU  - Farolan MJ
FAU - McDonald, A
AU  - McDonald A
FAU - Manaligod, J R
AU  - Manaligod JR
FAU - Das Gupta, T K
AU  - Das Gupta TK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Melanoma/*ultrastructure
MH  - Middle Aged
MH  - Nucleolus Organizer Region/*pathology
MH  - Prognosis
MH  - Silver Staining/methods
MH  - Skin Neoplasms/*ultrastructure
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - 10.1111/j.1600-0560.1994.tb00718.x [doi]
PST - ppublish
SO  - J Cutan Pathol. 1994 Dec;21(6):494-9. doi: 10.1111/j.1600-0560.1994.tb00718.x.