PMID- 7699571
OWN - NLM
STAT- MEDLINE
DCOM- 19950502
LR  - 20190710
IS  - 0022-3573 (Print)
IS  - 0022-3573 (Linking)
VI  - 46
IP  - 10
DP  - 1994 Oct
TI  - Sympathomimetic actions of methylenedioxymethamphetamine in rat and rabbit 
      isolated cardiovascular tissues.
PG  - 826-32
AB  - The aim of this study was to investigate the actions of 
      methylenedioxymethamphetamine (MDMA) in several isolated cardiovascular tissues. 
      In spontaneously beating rat atria, concentration-dependent positive chronotropic 
      responses to MDMA and amphetamine were blocked by the neuronal-uptake inhibitor 
      desipramine (1 microM) and the beta-adrenoceptor antagonist propranolol (1 
      microM). In atria incubated with [3H]noradrenaline to label transmitter stores, 
      10 microM MDMA and 1 microM amphetamine increased the resting outflow of 
      radioactivity, while 1 microM desipramine had no effect on resting outflow. The 
      MDMA- and amphetamine-induced release of radioactivity were blocked by 1 microM 
      desipramine. MDMA, amphetamine and desipramine each enhanced the electrical 
      stimulation-induced (2 Hz, 30-s train) release of radioactivity; the enhancing 
      effects of MDMA and amphetamine were blocked by 1 microM desipramine. In rat 
      isolated perfused hearts, MDMA (1 and 10 microM) increased heart rate by a 
      similar amount to the increase caused by noradrenaline (10 and 50 nM). MDMA also 
      induced dysrhythmias in 7 out of 11 rat isolated perfused heart preparations. In 
      rabbit isolated perfused and superfused ear arteries preloaded with 
      [3H]noradrenaline, MDMA increased the resting release of radioactivity by 230 +/- 
      18% (n = 6) of control resting release; the increase was accompanied by a rise in 
      perfusion pressure of 17 +/- 7 mmHg (n = 6). MDMA also facilitated the 
      vasoconstrictor responses to noradrenaline (3-9 ng) and perivascular nerve 
      stimulation (1-5 Hz, 10-s train). MDMA-induced vasoconstriction and the 
      facilitation of vasoconstrictor responses to noradrenaline and electrical 
      stimulation were blocked by 1 microM desipramine.(ABSTRACT TRUNCATED AT 250 
      WORDS)
FAU - Fitzgerald, J L
AU  - Fitzgerald JL
AD  - Department of Pharmacology, University of Melbourne, Victoria, Australia.
FAU - Reid, J J
AU  - Reid JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Pharm Pharmacol
JT  - The Journal of pharmacy and pharmacology
JID - 0376363
RN  - 0 (Sympathomimetics)
RN  - CK833KGX7E (Amphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - TG537D343B (Desipramine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Amphetamine/pharmacology
MH  - Animals
MH  - Desipramine/pharmacology
MH  - Female
MH  - Heart Rate/*drug effects
MH  - In Vitro Techniques
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/antagonists & inhibitors/*pharmacology
MH  - Norepinephrine/pharmacology
MH  - Rabbits
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stimulation, Chemical
MH  - Sympathomimetics/*pharmacology
EDAT- 1994/10/01 00:00
MHDA- 1994/10/01 00:01
CRDT- 1994/10/01 00:00
PHST- 1994/10/01 00:00 [pubmed]
PHST- 1994/10/01 00:01 [medline]
PHST- 1994/10/01 00:00 [entrez]
AID - 10.1111/j.2042-7158.1994.tb03738.x [doi]
PST - ppublish
SO  - J Pharm Pharmacol. 1994 Oct;46(10):826-32. doi: 
      10.1111/j.2042-7158.1994.tb03738.x.