PMID- 7699914
OWN - NLM
STAT- MEDLINE
DCOM- 19950501
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 53
IP  - 3
DP  - 1995 Mar
TI  - [Heavy chain disease].
PG  - 730-5
AB  - Heavy chain diseases (HCDs) are monoclonal, lymphoproliferative disorders 
      characterized by the production of incomplete heavy chains, devoid of light 
      chains. Since the first report of gamma-HCD in 1964, alpha-HCD and mu-HCD have 
      also been described. The clinical features of gamma-HCD may vary considerably. In 
      contrast, alpha-HCD primarily involves the secretory IgA system and mainly the 
      digestive tract. Its clinical pattern is strikingly uniform. alpha-HCD is the 
      most common of the HCDs, while mu-HCD is relatively rare. The demonstration of 
      Bence Jones proteins in the urine in association with lymphoproliferative 
      disorders and vacuolated plasma cells in the bone marrow deserves further 
      investigation for mu-HCD. Recently, two disease entities related to molecular 
      abnormalities of heavy chains have been reported; heavy-chain-associated 
      amyloidosis and heavy chain deposition disease.
FAU - Nomura, S
AU  - Nomura S
AD  - Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital.
FAU - Kanoh, T
AU  - Kanoh T
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - *Heavy Chain Disease
MH  - Humans
MH  - Immunoproliferative Small Intestinal Disease
MH  - Male
MH  - Middle Aged
RF  - 22
EDAT- 1995/03/01 00:00
MHDA- 1995/03/01 00:01
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 1995/03/01 00:01 [medline]
PHST- 1995/03/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 1995 Mar;53(3):730-5.