PMID- 7699954
OWN - NLM
STAT- MEDLINE
DCOM- 19950501
LR  - 20110801
IS  - 0385-2385 (Print)
IS  - 0385-2385 (Linking)
VI  - 37
IP  - 1
DP  - 1995 Jan
TI  - [A case of renal vein thrombosis and pulmonary embolism associated with diffuse 
      membranous glomerulonephritis: the usefulness of low-molecular-weight heparin and 
      urokinase therapy].
PG  - 49-56
AB  - We report a case of renal vein thrombosis (RVT) and pulmonary embolism associated 
      with diffuse membranous glomerulonephritis. A 44-year-old Japanese male was 
      referred to the Nephrology Department with heavy proteinuria. Renal biopsy 
      revealed diffuse membranous glomerulonephritis and we administered PSL 30mg/day 
      and dipyridamole 300mg/day. Three weeks later, he was admitted with severe chest 
      pain, dyspnea and massive proteinuria. RVT and pulmonary embolism were detected 
      on CT scan and perfusion lung scan. After a few days of continuous intravenous 
      unfractionated heparin (UFH) therapy, we used 72 U (anti-FXa)/kg of intravenous 
      low-molecular-weight heparin (LMWH) every 12 hours for 10 days. He also received 
      urokinase at the dose of 120,000 U/day for 4 weeks and long-term therapy with 
      warfarin potassium at the dose of 3 mg/day. One month later, the thrombi in the 
      pulmonary arteries and inferior vena cava disappeared on CT scan and perfusion 
      lung scan. LMWHs have a longer biological half-life and a lower bleeding tendency 
      than UFH for an equivalent antithrombotic effect. This case indicates that 
      intermittent intravenous LMWH administration combined with urokinase is effective 
      against RVT and pulmonary embolism without any side effect.
FAU - Irie, F
AU  - Irie F
AD  - Department of Internal Medicine, Tsukuba Gakuen Hospital, Ibaraki, Japan.
FAU - Kikuchi, H
AU  - Kikuchi H
FAU - Hibino, T
AU  - Hibino T
FAU - Sato, M
AU  - Sato M
FAU - Yamaguchi, N
AU  - Yamaguchi N
FAU - Kobayashi, M
AU  - Kobayashi M
FAU - Tojo, S
AU  - Tojo S
FAU - Koyama, A
AU  - Koyama A
LA  - jpn
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Jinzo Gakkai Shi
JT  - Nihon Jinzo Gakkai shi
JID - 7505731
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - EC 3.4.21.73 (Urokinase-Type Plasminogen Activator)
SB  - IM
MH  - Adult
MH  - Glomerulonephritis, Membranous/*complications
MH  - Heparin, Low-Molecular-Weight/*therapeutic use
MH  - Humans
MH  - Male
MH  - Pulmonary Embolism/*drug therapy/etiology
MH  - *Renal Veins
MH  - Thrombolytic Therapy
MH  - Thrombosis/*drug therapy/etiology
MH  - Urokinase-Type Plasminogen Activator/*therapeutic use
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Jinzo Gakkai Shi. 1995 Jan;37(1):49-56.