PMID- 7700573
OWN - NLM
STAT- MEDLINE
DCOM- 19950504
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 180
IP  - 2
DP  - 1994 Oct 24
TI  - Beta 1-adrenergic mechanism is involved in stress-induced increase in arousal.
PG  - 167-70
AB  - It has been shown that 1 h restraint shortens pentobarbital (PbNa)-induced 
      sleeping time and that brain corticotropin-releasing hormone (CRH) is involved in 
      the mechanism by which restraint shortens. PbNa-induced sleeping time. The 
      present study was designed to further examine the mechanism of the antagonistic 
      effect of 1 h restraint on PbNa in rats. Intracerebroventricular (i.c.v.) 
      administration of propranolol and metoprolol, but not butoxamine reversed the 
      shortening of PbNa-induced sleeping time by 1 h restraint. The i.c.v. 
      administration of phentolamine blocked the shortening of PbNa-induced sleeping 
      time by restraint, while the same dose of phentolamine prolonged the sleeping 
      time in unrestrained rats. Atropine did not affect the PbNa-induced sleeping time 
      in restrained rats. These results suggest that in addition to CRH, the brain beta 
      1-adrenergic system is involved in the restraint stress-induced increase in 
      arousal.
FAU - Shibasaki, T
AU  - Shibasaki T
AD  - Department of Medicine, Tokyo Women's Medical College, Japan.
FAU - Yamada, K
AU  - Yamada K
FAU - Yamauchi, N
AU  - Yamauchi N
FAU - Imaki, T
AU  - Imaki T
FAU - Hotta, M
AU  - Hotta M
FAU - Demura, H
AU  - Demura H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Receptors, Adrenergic, beta-1)
RN  - 0NM31M53PW (Butoxamine)
RN  - 7C0697DR9I (Atropine)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - 9Y8NXQ24VQ (Propranolol)
RN  - GEB06NHM23 (Metoprolol)
RN  - I4744080IR (Pentobarbital)
RN  - Z468598HBV (Phentolamine)
SB  - IM
MH  - Animals
MH  - Arousal/*physiology
MH  - Atropine/pharmacology
MH  - Butoxamine/pharmacology
MH  - Corticotropin-Releasing Hormone/metabolism
MH  - Hypothalamus/metabolism
MH  - Male
MH  - Metoprolol/pharmacology
MH  - Pentobarbital/pharmacology
MH  - Phentolamine/pharmacology
MH  - Propranolol/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Adrenergic, beta-1/drug effects/*physiology
MH  - Restraint, Physical
MH  - Sleep/drug effects
MH  - Sleep Initiation and Maintenance Disorders/etiology/*physiopathology
MH  - Stress, Physiological/complications/*physiopathology
EDAT- 1994/10/24 00:00
MHDA- 1994/10/24 00:01
CRDT- 1994/10/24 00:00
PHST- 1994/10/24 00:00 [pubmed]
PHST- 1994/10/24 00:01 [medline]
PHST- 1994/10/24 00:00 [entrez]
AID - 0304-3940(94)90513-4 [pii]
AID - 10.1016/0304-3940(94)90513-4 [doi]
PST - ppublish
SO  - Neurosci Lett. 1994 Oct 24;180(2):167-70. doi: 10.1016/0304-3940(94)90513-4.