PMID- 7700649
OWN - NLM
STAT- MEDLINE
DCOM- 19950503
LR  - 20181130
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 10
IP  - 6
DP  - 1995 Mar 16
TI  - Localization of the human HER4/erbB-4 gene to chromosome 2.
PG  - 1235-7
AB  - The HER4/erbB-4 gene has been isolated as the fourth member of the human EGFR 
      subfamily of tyrosine kinases and has been reported to encode a receptor for 
      NDF/heregulin. In the present study we determined the chromosomal location of the 
      HER4/erbB-4 gene within the human genome. Using human cDNA probes in fluorescence 
      in situ hybridization (FISH), we mapped the HER4/erbB-4 gene to human chromosome 
      2q33.3-34. This finding established that also the HER4/erbB-4 gene is located in 
      close vicinity of homeobox and collagen gene loci, as is the case for the related 
      EGFR, erbB-2/neu and erbB-3. Aberrations of this chromosomal region associated 
      with T cell leukemias and lymphomas as well as alveolar rhabdomyosarcomas raise 
      the possibility that HER4/erbB-4 might be activated in these tumour types.
FAU - Zimonjic, D B
AU  - Zimonjic DB
AD  - Laboratory of Biology, National Cancer Institute, National Institutes of Health, 
      Bethesda, Maryland.
FAU - Alimandi, M
AU  - Alimandi M
FAU - Miki, T
AU  - Miki T
FAU - Popescu, N C
AU  - Popescu NC
FAU - Kraus, M H
AU  - Kraus MH
LA  - eng
PT  - Journal Article
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (DNA, Complementary)
RN  - EC 2.7.10.1 (ERBB4 protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.10.1 (Receptor, ErbB-4)
SB  - IM
GS  - HER4
GS  - erbB-4
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 2
MH  - DNA, Complementary
MH  - ErbB Receptors/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Receptor, ErbB-4
EDAT- 1995/03/16 00:00
MHDA- 1995/03/16 00:01
CRDT- 1995/03/16 00:00
PHST- 1995/03/16 00:00 [pubmed]
PHST- 1995/03/16 00:01 [medline]
PHST- 1995/03/16 00:00 [entrez]
PST - ppublish
SO  - Oncogene. 1995 Mar 16;10(6):1235-7.