PMID- 7701542
OWN - NLM
STAT- MEDLINE
DCOM- 19950428
LR  - 20190821
IS  - 0039-128X (Print)
IS  - 0039-128X (Linking)
VI  - 59
IP  - 11
DP  - 1994 Nov
TI  - The activities of 5 beta-reductase and 11 beta-hydroxysteroid dehydrogenase in 
      essential hypertension.
PG  - 656-60
AB  - The activities of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) and 5 
      beta-reductase were analyzed in 39 normotensive controls and 128 patients with 
      essential hypertension. The activity of 11 beta-HSD was obtained by dividing the 
      24-hour urinary tetrahydrocortisone by the sum of tetrahydrocortisol (THF) and 
      allotetrahydrocortisol (aTHF), whereas the activity of 5 beta-reductase was 
      obtained by dividing the 24-hour urinary THF by aTHF. The activity of 5 
      beta-reductase was significantly lower in essential hypertensives compared with 
      normotensive controls (P < 0.05). However, the activity of 11 beta-HSD did not 
      differ between normotensive controls and essential hypertensives. A positive 
      correlation between the activities of 11 beta-HSD and 5 beta-reductase was 
      observed in essential hypertensives (r = 0.60, P < 0.01). Neither 11 beta-HSD nor 
      5 beta-reductase activity correlated with indices of renal mineralocorticoid 
      receptor activation, which were assessed by determination of plasma potassium and 
      urinary excretion of sodium as well as potassium. Taken together, these results 
      suggest that disturbances of one of the inactivation pathways of cortisol may 
      contribute to the pathogenesis of hypertension.
FAU - Iki, K
AU  - Iki K
AD  - Second Department of Internal Medicine, School of Medicine, Kanazawa University, 
      Japan.
FAU - Miyamori, I
AU  - Miyamori I
FAU - Hatakeyama, H
AU  - Hatakeyama H
FAU - Yoneda, T
AU  - Yoneda T
FAU - Takeda, Y
AU  - Takeda Y
FAU - Takeda, R
AU  - Takeda R
FAU - Dai, Q L
AU  - Dai QL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Steroids
JT  - Steroids
JID - 0404536
RN  - EC 1.- (Oxidoreductases)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenases)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenases
MH  - Adult
MH  - Female
MH  - Humans
MH  - Hydrocortisone/*metabolism
MH  - Hydroxysteroid Dehydrogenases/*metabolism
MH  - Hypertension/*enzymology
MH  - Male
MH  - Middle Aged
MH  - Oxidoreductases/*metabolism
MH  - Reference Values
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - 0039-128X(94)90022-1 [pii]
AID - 10.1016/0039-128x(94)90022-1 [doi]
PST - ppublish
SO  - Steroids. 1994 Nov;59(11):656-60. doi: 10.1016/0039-128x(94)90022-1.