PMID- 7701941
OWN - NLM
STAT- MEDLINE
DCOM- 19950502
LR  - 20061115
IS  - 0001-6772 (Print)
IS  - 0001-6772 (Linking)
VI  - 152
IP  - 4
DP  - 1994 Dec
TI  - A morphometric study of the effect of bilateral cervical sympathetic 
      ganglionectomy on the architecture of pial arteries in spontaneously hypertensive 
      and normotensive rats.
PG  - 407-18
AB  - The influence of the cranial sympathetic nerves on the architecture of pial 
      arteries in normo- and hypertension was examined. For this purpose the effect of 
      bilateral superior cervical ganglionectomy was evaluated in normotensive rats 
      (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). The operations 
      were performed at the age of 1 wk, which is just prior to the onset of ganglionic 
      transmission. The length of the inner media contour was measured and the media 
      cross-sectional area was determined planimetrically, with computerized 
      digitalization of projected photographic images of transversely sectioned pial 
      arteries. Four wk after sympathectomy there was a 20% reduction in media 
      cross-sectional area and a consequent reduction in the ratio between media area 
      and calculated luminal radius in the major pial arteries at the base of the brain 
      in WKY but not in SHRSP. Conversely, in small pial arteries linear regression 
      analysis showed that in WKY subjected to ganglionectomy the relationship between 
      media cross-sectional area and luminal radius was significantly larger in 
      arteries with a radius less than 21 microns compared to untreated WKY. No such 
      effect was seen in the corresponding SHRSP vessels. In addition, the 
      cross-sectional area of the internal elastic membrane (IEM) in the basilar 
      arteries of WKY was measured by means of a computerized image-analysing system. 
      Mean cross-sectional area of the IEM was approximately 45% larger following SE 
      than in control animals. The present findings propose a 'trophic' role for the 
      sympathetic perivascular nerves in large pial arteries of the rat. The increased 
      media-radius ratio in the small pial arteries of the WKY following sympathectomy 
      might reflect a compensatory hypertrophy due to reduced protection from the 
      larger arteries against the pressure load. The inability to detect any 
      morphometrically measurable effect of the sympathectomy in the cerebral arteries 
      of SHRSP is probably explained by a marked growth-stimulating effect of the high 
      pressure load in these animals.
FAU - Kahrstrom, J
AU  - Kahrstrom J
AD  - Department of Medical Cell Research, University of Lund, Sweden.
FAU - Nordborg, C
AU  - Nordborg C
FAU - Hardebo, J E
AU  - Hardebo JE
FAU - Owman, C
AU  - Owman C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Physiol Scand
JT  - Acta physiologica Scandinavica
JID - 0370362
SB  - IM
MH  - Animals
MH  - Arteries/anatomy & histology
MH  - Body Weight
MH  - Cerebral Arteries/physiology
MH  - Female
MH  - Ganglia, Sympathetic
MH  - *Ganglionectomy
MH  - Male
MH  - Membranes/anatomy & histology
MH  - Organ Size
MH  - Pia Mater/*blood supply
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred Strains
MH  - Rats, Inbred WKY
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - 10.1111/j.1748-1716.1994.tb09823.x [doi]
PST - ppublish
SO  - Acta Physiol Scand. 1994 Dec;152(4):407-18. doi: 
      10.1111/j.1748-1716.1994.tb09823.x.