PMID- 7702253
OWN - NLM
STAT- MEDLINE
DCOM- 19950502
LR  - 20131121
IS  - 0151-9638 (Print)
IS  - 0151-9638 (Linking)
VI  - 121
IP  - 4
DP  - 1994
TI  - [Nodular and granulomatous form of periarteritis nodosa caused by the hepatitis B 
      virus].
PG  - 325-7
AB  - Polyarteritis nodosa (PAN) is, in rare cases, associated with subcutaneous 
      nodules and pathology does not usually show the presence of peri and 
      extravascular granulomas. When present in patients with hepatitis B virus (HBV) 
      related PAN these facts demonstrate that classification of PAN is not 
      homogeneous. CASE REPORT. A patient infected by HBV developed a PAN demonstrated 
      by clinical symptoms and pathology. The disease was characterized by the presence 
      of subcutaneous nodules and histologically by peri- and extra-vascular granuloma 
      which surrounded necrosis of medium-sized vessels. Outcome was also unusual in 
      the patient who did not respond to the association of plasma exchanges and 
      antiviral agents and was only slightly improved by steroids and cyclophosphamide. 
      COMMENTS. HBV-related PAN is considered to be an immune complex disorder. In the 
      present case report granuloma were present as observed in Churg Strauss syndrome 
      or Wegener's granulomatosis which are the consequence of other pathogenetic 
      mechanisms as anticytoplasmic neutrophil antibodies (ANCA). This case reports 
      underlines the heterogeneity of the PAN group of vasculitis and the probable role 
      for various pathogenetic mechanisms.
FAU - Turki, S
AU  - Turki S
AD  - Service de Medecine Interne, Hopital Avicenne, Bobigny, France.
FAU - Guillevin, L
AU  - Guillevin L
FAU - Dallot, A
AU  - Dallot A
FAU - Jarrousse, B
AU  - Jarrousse B
FAU - Vernier, I
AU  - Vernier I
FAU - Laroche, L
AU  - Laroche L
FAU - Pourrat, J
AU  - Pourrat J
FAU - Amouroux, J
AU  - Amouroux J
LA  - fre
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Forme cutanee nodulaire et granulomateuse d'une periarterite noueuse liee au 
      virus de l'hepatite B.
PL  - France
TA  - Ann Dermatol Venereol
JT  - Annales de dermatologie et de venereologie
JID - 7702013
RN  - 0 (Antiviral Agents)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Antiviral Agents/therapeutic use
MH  - Cyclophosphamide/therapeutic use
MH  - Granuloma/drug therapy/pathology/*virology
MH  - *Hepatitis B virus
MH  - Humans
MH  - Male
MH  - Methylprednisolone/therapeutic use
MH  - Middle Aged
MH  - Plasma Exchange
MH  - Polyarteritis Nodosa/drug therapy/pathology/*virology
MH  - Skin Diseases/drug therapy/pathology/*virology
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PST - ppublish
SO  - Ann Dermatol Venereol. 1994;121(4):325-7.