PMID- 7703535
OWN - NLM
STAT- MEDLINE
DCOM- 19950510
LR  - 20220318
IS  - 1045-4861 (Print)
IS  - 1045-4861 (Linking)
VI  - 6
IP  - 1
DP  - 1995 Spring
TI  - Effects of particulate high-density polyethylene and titanium alloy on tissue 
      ingrowth into bone harvest chamber in rabbits.
PG  - 27-33
AB  - The purpose of this study was to determine whether small, phagocytosable 
      particles of titanium alloy (Ti) and high-density polyethylene (HDPE) have an 
      adverse effect on bone ingrowth. The bone harvest chamber (BHC) was implanted 
      bilaterally in the proximal tibial metaphysis of six mature rabbits. The BHC has 
      a transverse 1-mm wide pore providing a continuous canal through the chamber for 
      tissue ingrowth. After an initial 6-week period for osseointegration of the BHC, 
      the contents of the canal were harvested repeatedly at 3 weekly intervals. This 
      could be done with the chamber in place, without disturbing its exterior surface 
      or the surrounding bone. The carrier solution, 1% sodium hyaluronate (Healon) was 
      implanted first. In subsequent implantations, Healon was mixed with particles of 
      HDPE or Ti averaging 4.7 +/- 2.1 and 3.0 +/- 2.6 microns, respectively. The 
      contralateral chamber was left empty and served as a control. The chambers were 
      harvested repeatedly, alternating experimental and control sides. The sections 
      from the control side, and those containing Healon alone demonstrated extensive 
      trabecular bone in a fibrovascular stroma. The sections containing Ti alloy 
      particles were qualitatively and quantitatively similar to the control sections 
      and those containing Healon, except for the presence of small black granules of 
      Ti alloy, dispersed in the fibrovascular stroma or phagocytosed by scattered 
      macrophages. The sections containing HDPE particles were infiltrated and engulfed 
      by mononuclear and multinuclear histiocytic cells in a highly fibrous stroma. The 
      majority of the multinucleated cells present were interpreted as being foreign 
      body giant cells.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Goodman, S
AU  - Goodman S
AD  - Division of Orthopaedic Surgery, Stanford University Medical Center, CA 
      94305-5326.
FAU - Aspenberg, P
AU  - Aspenberg P
FAU - Song, Y
AU  - Song Y
FAU - Doshi, A
AU  - Doshi A
FAU - Regula, D
AU  - Regula D
FAU - Lidgren, L
AU  - Lidgren L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Appl Biomater
JT  - Journal of applied biomaterials : an official journal of the Society for 
      Biomaterials
JID - 9011484
RN  - 0 (Alloys)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polyethylenes)
RN  - 12743-70-3 (titanium alloy (TiAl6V4))
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Alloys
MH  - Animals
MH  - Biocompatible Materials
MH  - Joint Prosthesis/*adverse effects
MH  - Male
MH  - Materials Testing
MH  - Microscopy, Electron, Scanning
MH  - Phagocytosis
MH  - Polyethylenes
MH  - *Prosthesis Failure
MH  - Rabbits
MH  - Titanium
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1002/jab.770060105 [doi]
PST - ppublish
SO  - J Appl Biomater. 1995 Spring;6(1):27-33. doi: 10.1002/jab.770060105.