PMID- 7703675
OWN - NLM
STAT- MEDLINE
DCOM- 19950509
LR  - 20061115
IS  - 0940-2993 (Print)
IS  - 0940-2993 (Linking)
VI  - 46
IP  - 6
DP  - 1994 Dec
TI  - Purkinje and granule cells distribution in the cerebellum of the rat following 
      prenatal exposure to low dose ionizing radiation.
PG  - 443-52
AB  - The effects of maternal exposure to a single dose of whole body irradiation (0.5 
      Gy) on gestational days (GD) 17, 18, 19, or 20 on the number of Purkinje and 
      granule cells in the pyramis of the cerebellar cortex was examined in the 
      offspring of Sprague Dawley rats at 21 and 28 days postnatally. The laterolateral 
      distribution of both granule and Purkinje cells in the pyramis were significantly 
      reduced (p < 0.001) from controls in rats irradiated on each of GD-17, 18, 19 and 
      20. There was a greater deficit in granule cell number with irradiation on GD-20 
      than on GD17 (p < 0.05). Purkinje cells were reduced in number with irradiation 
      on GD-17 and GD-20; however, the decrease did not correspond to the degree of 
      reduction in the number of granule cells. There was a greater reduction of both 
      granule and Purkinje cells in the vermis with irradiation on GD-17, whereas on 
      GD-20, both granule (p < 0.05) and Purkinje cells (p < 0.001) were more reduced 
      in the lateral hemispheres. The GC/PC ratio was smaller in rats irradiated on 
      GD-20 than on GD-17. The GC/PC ratio between the irradiated animals and the 
      controls were relatively similar. The findings show that irradiation does not 
      affect the population of granule cells directly, but rather indirectly. The 
      reduction in the number of granule cells could be an indirect consequence of 
      reduced critical interaction with Purkinje cells. These results suggest that a 
      direct relationship exists between the proliferation, migration, development, and 
      maturation of granule cells and their induction by Purkinje cells.
FAU - Ralcewicz, T A
AU  - Ralcewicz TA
AD  - Department of Anatomy, University of Manitoba, Winnipeg, Canada.
FAU - Persaud, T V
AU  - Persaud TV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Exp Toxicol Pathol
JT  - Experimental and toxicologic pathology : official journal of the Gesellschaft fur 
      Toxikologische Pathologie
JID - 9208920
SB  - IM
MH  - Animals
MH  - Cerebellar Cortex/*cytology/*radiation effects
MH  - Female
MH  - Neurons/radiation effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Purkinje Cells/radiation effects
MH  - Rats
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - S0940-2993(11)80058-8 [pii]
AID - 10.1016/S0940-2993(11)80058-8 [doi]
PST - ppublish
SO  - Exp Toxicol Pathol. 1994 Dec;46(6):443-52. doi: 10.1016/S0940-2993(11)80058-8.