PMID- 7704946
OWN - NLM
STAT- MEDLINE
DCOM- 19950508
LR  - 20190706
IS  - 0009-8981 (Print)
IS  - 0009-8981 (Linking)
VI  - 231
IP  - 1
DP  - 1994 Nov
TI  - Plasma cholesteryl ester transfer in patients with non-insulin dependent diabetes 
      mellitus.
PG  - 29-38
AB  - Plasma newly synthesised cholesteryl ester transfer (NCET) rates from high 
      density lipoproteins (HDL) to very low density lipoproteins (VLDL) and low 
      density lipoproteins lipoproteins (LDL) were measured in 26 patients with 
      non-insulin dependent diabetes mellitus (NIDDM), 26 healthy subjects with closely 
      matching plasma triglyceride (TG) levels and 10 normolipidaemic healthy 
      individuals. In addition, insulin mediated glucose uptake was measured in the 
      NIDDM patients and the normolipidaemic subjects. Rates of NCET were significantly 
      (P < 0.05) elevated in NIDDM patients compared with healthy normolipidaemic 
      individuals but were similar to rates in healthy subjects with closely matching 
      TG levels. In all groups of subjects plasma NCET was significantly (P < 0.001) 
      correlated with plasma TG concentration. In NIDDM patients correlations between 
      NCET and plasma glucose (r = 0.489, P = 0.011) independently of plasma TG levels, 
      and glycated haemoglobin levels (r = 0.430, P = 0.028) were also recorded. 
      Insulin mediated glucose uptake was unrelated to plasma NCET rates in the study. 
      These data suggest that in NIDDM patients under good diabetic control elevated 
      plasma NCET rates are mainly due to hypertriglyceridaemia and a specific and 
      possibly stimulatory effect of diabetes on these rates may be seen only in 
      patients with poorly controlled diabetes.
FAU - Sutherland, W H
AU  - Sutherland WH
AD  - Department of Medicine, University of Otago Medical School, Dunedin, New Zealand.
FAU - Walker, R J
AU  - Walker RJ
FAU - Lewis-Barned, N J
AU  - Lewis-Barned NJ
FAU - Pratt, H
AU  - Pratt H
FAU - Tillman, H C
AU  - Tillman HC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (CETP protein, human)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cholesterol Ester Transfer Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (Lipoproteins)
RN  - 0 (Triglycerides)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carrier Proteins/*blood
MH  - Cholesterol Ester Transfer Proteins
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Glucose/pharmacokinetics
MH  - *Glycoproteins
MH  - Humans
MH  - Insulin/pharmacology
MH  - Lipid Metabolism
MH  - Lipids/blood
MH  - Lipoproteins/blood
MH  - Male
MH  - Middle Aged
MH  - Triglycerides/blood
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - 0009-8981(94)90251-8 [pii]
AID - 10.1016/0009-8981(94)90251-8 [doi]
PST - ppublish
SO  - Clin Chim Acta. 1994 Nov;231(1):29-38. doi: 10.1016/0009-8981(94)90251-8.