PMID- 7704948
OWN - NLM
STAT- MEDLINE
DCOM- 19950508
LR  - 20190706
IS  - 0009-8981 (Print)
IS  - 0009-8981 (Linking)
VI  - 231
IP  - 1
DP  - 1994 Nov
TI  - Different time courses of cardiac contractile proteins after acute myocardial 
      infarction.
PG  - 47-60
AB  - For the first time we have compared time courses of cardiac myosin light chain-1 
      (MLC-1), beta-type myosin heavy chain (MHC), troponin T (TnT), myoglobin, 
      creatine kinase (CK) and CKMB in the same patients with acute myocardial 
      infarction (AMI). Blood samples were serially collected in 23 patients with 
      first-time AMI. All but 3 patients received intravenous thrombolytic treatment. 
      TnT and MLC-1 time courses were biphasic in most patients and showed two distinct 
      peaks in 13 and 8 patients, respectively. MHC time courses were usually 
      monophasic. Only 1 patient showed a biphasic MHC time course with two distinct 
      peak values. Although MHC and MLC were lower by about the fourth day after onset 
      of AMI in early reperfused patients, reperfusion did not qualitatively alter MLC 
      and MHC release (no significant influence on the first appearance in blood or on 
      time to peak). MLC and MHC peaks correlated closely (r = 0.75, P = 0.0001), 
      whereas TnT peaks were correlated less closely with MLC or MHC peaks (r = 0.58 
      each, P < 0.007). Peak values of all cardiac contractile proteins correlated 
      closely and significantly with CKMB peaks (0.75 < or = r < or = 0.81, P < or = 
      0.0006). Myoglobin was the first marker to increase in blood after AMI and showed 
      the earliest peaks, whereas MHC increased latest showing the latest peaks. TnT 
      increased significantly (P = 0.0001) earlier than MLC and MHC. These results can 
      be explained by the impact of the intracellular compartmentation of a cardiac 
      protein on the rapidity with which it is released after AMI.
FAU - Mair, J
AU  - Mair J
AD  - Department of Medical Chemistry, University of Innsbruck Medical School, Austria.
FAU - Wagner, I
AU  - Wagner I
FAU - Jakob, G
AU  - Jakob G
FAU - Lechleitner, P
AU  - Lechleitner P
FAU - Dienstl, F
AU  - Dienstl F
FAU - Puschendorf, B
AU  - Puschendorf B
FAU - Michel, G
AU  - Michel G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Biomarkers)
RN  - 0 (Contractile Proteins)
RN  - 0 (Isoenzymes)
RN  - 0 (Myoglobin)
RN  - 0 (Troponin)
RN  - 0 (Troponin T)
RN  - EC 2.7.3.2 (Creatine Kinase)
RN  - EC 3.6.4.1 (Myosins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/analysis
MH  - Contractile Proteins/*metabolism/pharmacokinetics
MH  - Creatine Kinase/metabolism/pharmacokinetics
MH  - Female
MH  - Humans
MH  - Isoenzymes
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*metabolism
MH  - Myocardium/chemistry
MH  - Myoglobin/blood/pharmacokinetics
MH  - Myosins/chemistry/metabolism/pharmacokinetics
MH  - Reperfusion
MH  - Time Factors
MH  - Troponin/metabolism/pharmacokinetics
MH  - Troponin T
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - 0009-8981(94)90253-4 [pii]
AID - 10.1016/0009-8981(94)90253-4 [doi]
PST - ppublish
SO  - Clin Chim Acta. 1994 Nov;231(1):47-60. doi: 10.1016/0009-8981(94)90253-4.