PMID- 7706114
OWN - NLM
STAT- MEDLINE
DCOM- 19950505
LR  - 20190515
IS  - 0018-067X (Print)
IS  - 0018-067X (Linking)
VI  - 74 ( Pt 3)
DP  - 1995 Mar
TI  - Population structure, stepwise mutations, heterozygote deficiency and their 
      implications in DNA forensics.
PG  - 274-85
AB  - In a substructured population the overall heterozygote deficiency can be 
      predicted from the number of subpopulations (s), their time of divergence (t), 
      and the nature of the mutations. At present the true mutational mechanisms at the 
      hypervariable DNA loci are not known. However, the two existing mutation models 
      (the infinite allele model (IAM) and the stepwise mutation model (SMM)) provide 
      some guides to predictions from which the possible effect of population 
      substructuring may be evaluated, assuming that the subpopulations do not exchange 
      any genes among them during evolution. The theory predicts that the loci with 
      larger mutation rate, and consequently showing greater heterozygosity within 
      subpopulations, should exhibit a smaller proportional heterozygote deficiency 
      (GST) and, hence, the effects of population substructuring should be minimal at 
      the hypervariable DNA loci (an order of magnitude smaller than that at the blood 
      group and protein loci). Applications of this theory to data on six Variable 
      Number of Tandem Repeat (VNTR) loci and five short tandem repeat (STR) loci in 
      the major cosmopolitan populations of the USA show that while the VNTR loci often 
      exhibit a large significant heterozygote deficiency, the STR loci do not show a 
      similar tendency. This discordant finding may be ascribed to the limitations, 
      coalescence and nondetectability of alleles associated with the restriction 
      fragment length polymorphism (RFLP) analysis through which the VNTR loci are 
      scored. Such limitations do not apply to the polymerase chain reaction (PCR) 
      method, through which the STR loci are scored. The implications of these results 
      are discussed in the context of the forensic use of DNA typing data.
FAU - Jin, L
AU  - Jin L
AD  - Center for Demographic and Population Genetics, Graduate School of Biomedical 
      Sciences, University of Texas, Houston 77225.
FAU - Chakraborty, R
AU  - Chakraborty R
LA  - eng
GR  - GM 41399/GM/NIGMS NIH HHS/United States
GR  - GM 45861/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Heredity (Edinb)
JT  - Heredity
JID - 0373007
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - DNA/*genetics
MH  - *Forensic Medicine
MH  - *Genetics, Population
MH  - *Heterozygote
MH  - Humans
MH  - Minisatellite Repeats
MH  - *Mutation
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
EDAT- 1995/03/01 00:00
MHDA- 1995/03/01 00:01
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 1995/03/01 00:01 [medline]
PHST- 1995/03/01 00:00 [entrez]
AID - 10.1038/hdy.1995.41 [doi]
PST - ppublish
SO  - Heredity (Edinb). 1995 Mar;74 ( Pt 3):274-85. doi: 10.1038/hdy.1995.41.