PMID- 7706440
OWN - NLM
STAT- MEDLINE
DCOM- 19950509
LR  - 20190825
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 57
IP  - 1-2
DP  - 1995 Mar
TI  - Opioid receptor-mediated suppression of humoral immune response in vivo and in 
      vitro: involvement of kappa opioid receptors.
PG  - 55-62
AB  - The selective kappa opioid receptor agonist MR 2034 exerted pronounced 
      suppression of plaque-forming cell (PFC) response following intraperitoneal 
      (i.p.) administration in the rat. Pretreatment with preferential kappa and mu 
      opioid receptor antagonists MR 2266 and naloxone, respectively, revealed that 
      this effect was mediated mainly by kappa, and to a low extent by mu opioid 
      receptors. Intracerebroventricular (i.c.v.) administration of quaternary 
      naltrexone (QNtx) moderately attenuated, whereas i.p. given QNtx completely 
      prevented the suppressive effect of MR 2034, suggesting a peripheral mechanism of 
      action, and only minor involvement of brain opioid receptors. MR 2034 markedly 
      decreased the PFC response of spleen cells obtained from in vivo immunized rats, 
      treated in vitro with the opiate. The immunosuppressive action of MR 2034 in 
      vitro was completely and partially blocked by equimolar concentrations of MR 2266 
      and naloxone, respectively. Antagonists alone produced stimulation of PFC 
      following i.p. administration in the rat, but did not affect PFC response upon in 
      vitro treatment. These results suggest that peripheral kappa opioid receptors 
      down-regulate primary humoral immune response in the rat, and that this effect 
      may be produced by direct interference with plasma cell activity.
FAU - Radulovic, J
AU  - Radulovic J
AD  - Immunology Research Center, Belgrade, Yugoslavia.
FAU - Miljevic, C
AU  - Miljevic C
FAU - Djergovic, D
AU  - Djergovic D
FAU - Vujic, V
AU  - Vujic V
FAU - Antic, J
AU  - Antic J
FAU - von Horsten, S
AU  - von Horsten S
FAU - Jankovic, B D
AU  - Jankovic BD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Benzomorphans)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Receptors, Opioid, kappa)
RN  - 36B82AMQ7N (Naloxone)
RN  - 56649-76-4 (MR 2266)
RN  - 57236-85-8 (MR 2034)
SB  - IM
MH  - Animals
MH  - Antibody Formation/drug effects
MH  - Benzomorphans/pharmacology
MH  - *Immune Tolerance
MH  - Immunosuppressive Agents/pharmacology
MH  - Male
MH  - Naloxone/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Opioid, kappa/*physiology
MH  - Sheep
EDAT- 1995/03/01 00:00
MHDA- 2000/06/01 09:00
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1995/03/01 00:00 [entrez]
AID - 0165-5728(94)00161-G [pii]
AID - 10.1016/0165-5728(94)00161-g [doi]
PST - ppublish
SO  - J Neuroimmunol. 1995 Mar;57(1-2):55-62. doi: 10.1016/0165-5728(94)00161-g.