PMID- 7707241
OWN - NLM
STAT- MEDLINE
DCOM- 19950508
LR  - 20190512
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 481 ( Pt 3)
IP  - Pt 3
DP  - 1994 Dec 15
TI  - Somatosensory regulation of renal function in the stroke-prone spontaneously 
      hypertensive rat.
PG  - 753-9
AB  - 1. Chloralose-urethane-anaesthetized Wistar rats and stroke-prone spontaneously 
      hypertensive rats (SHRSP) were prepared for measuring renal function. 2. 
      Bilateral brachial nerve stimulation for 15 min, at 1.3 Hz (15 V, 0.2 ms), 
      increased blood pressure from 119 +/- 2 to 151 +/- 6 mmHg (P < 0.01) in Wistar 
      rats and from 181 +/- 6 to 203 +/- 6 mmHg (P < 0.05) in SHRSP; renal perfusion 
      pressure was mechanically regulated at prestimulus levels but renal blood flow 
      (4.1 +/- 0.7 ml min-1 g-1 in Wistar rats and 3.4 +/- 0.3 ml min-1 g-1 in SHRSP) 
      and glomerular filtration rate (1.18 +/- 0.09 ml min-1 g-1 in Wistar rats and 
      0.88 +/- 0.01 ml min-1 g-1 in SHRSP) decreased between 5 and 30% (P < 
      0.05-0.001). 3. During brachial nerve stimulation, urine flow (13.8 +/- 2.2 
      microliters min-1 g-1) and absolute and fractional sodium excretion (3.70 +/- 
      0.64 mumol min-1 g-1 and 2.06 +/- 0.23%) decreased by 60-70% in the Wistar rats 
      (P < 0.01-0.001) and the responses were unaffected by vagotomy or carotid sinus 
      denervation. In the SHRSP, urine flow rate (9.74 +/- 2.52 microliters min-1 g-1) 
      and absolute and fractional sodium excretion (1.98 +/- 0.59 mumol min-1 g-1 and 
      1.41 +/- 0.28%) decreased by 15-30% (P < 0.05-0.01), decreases which were 
      significantly (P < 0.05) smaller than those observed in the Wistar rats. 
      Moreover, the responses were some 40-60% larger in the vagotomized and carotid 
      sinus-denervated SHRSP. 4. The influence of vagal and carotid sinus afferent 
      nerves on the somatosensory-induced renal responses in the Wistar rats was small, 
      whereas in the SHRSP they appeared to exert a marked tonic inhibitory effect. It 
      is concluded that there is excessive baroreceptor restraint on neural regulation 
      of renal function in the SHRSP.
FAU - Davis, G
AU  - Davis G
AD  - Department of Physiology, Medical School, Birmingham, UK.
FAU - Johns, E J
AU  - Johns EJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - 9NEZ333N27 (Sodium)
SB  - IM
MH  - Animals
MH  - Blood Pressure/physiology
MH  - Carotid Sinus/physiopathology
MH  - Diuresis
MH  - Glomerular Filtration Rate
MH  - Heart Atria/innervation
MH  - Heart Rate/*physiology
MH  - Hypertension/*physiopathology
MH  - Kidney/*innervation/physiopathology
MH  - Male
MH  - Pressoreceptors/*physiopathology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Wistar
MH  - Renal Circulation
MH  - Sodium/metabolism
MH  - Stress, Physiological/physiopathology
MH  - Sympathetic Nervous System/physiopathology
MH  - Vagus Nerve/physiopathology
PMC - PMC1155916
EDAT- 1994/12/15 00:00
MHDA- 1994/12/15 00:01
PMCR- 1995/12/15
CRDT- 1994/12/15 00:00
PHST- 1994/12/15 00:00 [pubmed]
PHST- 1994/12/15 00:01 [medline]
PHST- 1994/12/15 00:00 [entrez]
PHST- 1995/12/15 00:00 [pmc-release]
AID - 10.1113/jphysiol.1994.sp020479 [doi]
PST - ppublish
SO  - J Physiol. 1994 Dec 15;481 ( Pt 3)(Pt 3):753-9. doi: 
      10.1113/jphysiol.1994.sp020479.