PMID- 7709342
OWN - NLM
STAT- MEDLINE
DCOM- 19950509
LR  - 20151119
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 19
IP  - 1
DP  - 1995 Jan
TI  - A genetic deficiency in calpastatin and isovalerylcarnitine treatment is 
      associated with enhanced hippocampal long-term potentiation.
PG  - 37-45
AB  - The Milan hypertensive strain (MHS) of rats, in addition to having hypertension, 
      is also characterized by a genetic deficiency in calpastatin, the endogenous 
      inhibitor of calpain. Since this protease has been implicated in long-term 
      potentiation (LTP), we have investigated whether induction of this form of 
      plasticity was altered in this strain of rats as compared to control animals 
      (Milan normotensive strain, MNS). Progressive induction of LTP by increasing 
      numbers of high frequency trains resulted in a greater degree of potentiation 
      measured with all inducing protocols in MHS as compared with MNS animals. This 
      difference was not related to the hypertension, since another hypertensive strain 
      (the SHR strain) and a segregated Milan hypertensive strain, expressing only the 
      hypertension but not the calpastatin deficiency (the MHNE strain), exhibited an 
      LTP indistinguishable from control rats. Treatment of MHNE rats for 2 months with 
      isovalerylcarnitine, a compound that increases calpain activity, also resulted in 
      a greater amount of LTP induced by high frequency trains. These effects were not 
      related to an enhancement of the NMDA receptor dependent component of responses 
      to burst stimulation. These results are consistent with the idea that conditions 
      under which calpain activation is facilitated are associated with a greater 
      degree of synaptic potentiation.
FAU - Muller, D
AU  - Muller D
AD  - Department of Pharmacology, CMU, Geneva, Switzerland.
FAU - Molinari, I
AU  - Molinari I
FAU - Soldati, L
AU  - Soldati L
FAU - Bianchi, G
AU  - Bianchi G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Calcium-Binding Proteins)
RN  - 31023-24-2 (3-methylbutyrylcarnitine)
RN  - 79079-11-1 (calpastatin)
RN  - EC 3.4.22.- (Calpain)
RN  - S7UI8SM58A (Carnitine)
SB  - IM
MH  - Animals
MH  - Calcium-Binding Proteins/*deficiency
MH  - Calpain/antagonists & inhibitors
MH  - Carnitine/*analogs & derivatives/deficiency
MH  - Hippocampus/*drug effects
MH  - Hypertension/genetics
MH  - *Long-Term Potentiation
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred Strains
MH  - Rats, Wistar
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1002/syn.890190106 [doi]
PST - ppublish
SO  - Synapse. 1995 Jan;19(1):37-45. doi: 10.1002/syn.890190106.