PMID- 7710939
OWN - NLM
STAT- MEDLINE
DCOM- 19950512
LR  - 20190515
IS  - 0007-0920 (Print)
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Linking)
VI  - 71
IP  - 4
DP  - 1995 Apr
TI  - Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of 
      human colon cancer cells by gamma-linolenic acid.
PG  - 744-52
AB  - In this study we have determined the effects of the n-6 essential fatty acid 
      gamma-linolenic acid (GLA) on the motility and invasive/metastatic nature of the 
      human colon cancer cell lines HT115, HT29 and HRT18. Cell motility was induced by 
      hepatocyte growth factor/scatter factor (HGF/SF) and measured by both colony 
      scattering and dissociation from carrier beads. Invasiveness was measured in 
      vitro by cellular invasion into extracellular matrix. At concentrations up to 100 
      microM (which had no effect on cell growth over the duration of the experiments) 
      both cell motility and invasion induced by HGF/SF were markedly reduced by GLA 
      and its lithium salt. The attachment of these cells to the extracellular matrix 
      components (Matrigel and fibronectin) was also inhibited. There were also changes 
      in the cell-surface E-cadherin, but not fibronectin receptor at similar 
      concentrations. It is concluded that n-6 essential fatty acids have the ability 
      to inhibit both motility and invasiveness of human colon cancer cells, perhaps by 
      modifying cell-surface adhesion molecules.
FAU - Jiang, W G
AU  - Jiang WG
AD  - Department of Surgery, University of Wales College of Medicine, Cardiff, UK.
FAU - Hiscox, S
AU  - Hiscox S
FAU - Hallett, M B
AU  - Hallett MB
FAU - Scott, C
AU  - Scott C
FAU - Horrobin, D F
AU  - Horrobin DF
FAU - Puntis, M C
AU  - Puntis MC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
RN  - 0 (Cadherins)
RN  - 0 (Linoleic Acids)
RN  - 0 (Receptors, Fibronectin)
RN  - 27YG812J1I (Arachidonic Acid)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - 78YC2MAX4O (gamma-Linolenic Acid)
RN  - 9KJL21T0QJ (Linoleic Acid)
SB  - IM
MH  - Arachidonic Acid/pharmacology
MH  - Cadherins/metabolism
MH  - Cell Adhesion/drug effects
MH  - Cell Line
MH  - Cell Movement/*drug effects
MH  - Colonic Neoplasms
MH  - Extracellular Matrix
MH  - Hepatocyte Growth Factor/antagonists & inhibitors/*pharmacology
MH  - Humans
MH  - Linoleic Acid
MH  - Linoleic Acids/pharmacology
MH  - *Neoplasm Invasiveness
MH  - Receptors, Fibronectin/metabolism
MH  - Tumor Cells, Cultured
MH  - gamma-Linolenic Acid/*pharmacology
PMC - PMC2033731
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
AID - 10.1038/bjc.1995.145 [doi]
PST - ppublish
SO  - Br J Cancer. 1995 Apr;71(4):744-52. doi: 10.1038/bjc.1995.145.