PMID- 7712461
OWN - NLM
STAT- MEDLINE
DCOM- 19950515
LR  - 20071114
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 55
IP  - 8
DP  - 1995 Apr 15
TI  - Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) 
      locus in aggressive pituitary tumors: evidence for a chromosome 13 tumor 
      suppressor gene other than RB.
PG  - 1613-6
AB  - Mice bearing retinoblastoma susceptibility gene (RB) germ-line mutations almost 
      invariably develop pituitary neoplasms. We therefore tested 17 patients with 
      pituitary tumors for loss of heterozygosity (LOH) using an RB sequence 
      polymorphism and 5 polymorphic microsatellite markers surrounding the RB gene on 
      the long arm of chromosome 13. In all of the 13 malignant or highly invasive 
      pituitary tumor cases, and in 4 of their respective metastases, a RB allele was 
      lost. In contrast, no LOH at the RB locus was detected in 4 benign pituitary 
      adenoma cases. Three invasive tumors also lost a portion of 13q, which included 
      D13s137, D13s133, and D13s118 telomeric and centromeric to RB, respectively. 
      Immunohistochemical analysis, however, revealed the presence of RB protein in 
      tumors with LOH and the RB locus. Therefore, although inactivation of RB may play 
      a role in the development of invasive pituitary adenomas and carcinomas in mice, 
      another tumor suppressor gene on 13q is likely involved in human pituitary tumor 
      progression. LOH of 13q markers may also be of predictive value in determining 
      the biological behavior of pituitary macroadenomas and their progression to 
      invasiveness and frank malignancy.
FAU - Pei, L
AU  - Pei L
AD  - Department of Medicine, Cedars-Sinai Research Institute-University of California 
      Los Angeles School of Medicine 90048, USA.
FAU - Melmed, S
AU  - Melmed S
FAU - Scheithauer, B
AU  - Scheithauer B
FAU - Kovacs, K
AU  - Kovacs K
FAU - Benedict, W F
AU  - Benedict WF
FAU - Prager, D
AU  - Prager D
LA  - eng
GR  - DK T-32 DK07682/DK/NIDDK NIH HHS/United States
GR  - DK02023/DK/NIDDK NIH HHS/United States
GR  - DK42792/DK/NIDDK NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Satellite)
RN  - 0 (Genetic Markers)
RN  - 0 (Retinoblastoma Protein)
SB  - IM
CIN - J Am Dent Assoc. 2017 Nov;148(11):e166. PMID: 28864062
GS  - RB
MH  - Alleles
MH  - Base Sequence
MH  - *Chromosome Deletion
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 13
MH  - DNA Primers
MH  - DNA, Satellite/genetics
MH  - Exons
MH  - *Genes, Retinoblastoma
MH  - *Genes, Tumor Suppressor
MH  - Genetic Markers
MH  - Humans
MH  - Immunohistochemistry
MH  - Molecular Sequence Data
MH  - Pituitary Neoplasms/*genetics/pathology
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Retinoblastoma Protein/analysis
EDAT- 1995/04/15 00:00
MHDA- 1995/04/15 00:01
CRDT- 1995/04/15 00:00
PHST- 1995/04/15 00:00 [pubmed]
PHST- 1995/04/15 00:01 [medline]
PHST- 1995/04/15 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1995 Apr 15;55(8):1613-6.