PMID- 7714614
OWN - NLM
STAT- MEDLINE
DCOM- 19950518
LR  - 20061115
IS  - 0022-3085 (Print)
IS  - 0022-3085 (Linking)
VI  - 82
IP  - 5
DP  - 1995 May
TI  - Expression of monocyte chemoattractant protein-1 in meningioma.
PG  - 874-8
AB  - Monocyte chemoattractant protein-1 (MCP-1), purified from glioma cell line 
      (U-105MG) culture fluid, attracts monocytes but not neutrophils. Macrophage 
      accumulation is one of the pathological features of meningioma. To investigate 
      the mechanism of macrophage infiltration into meningioma, the expression and 
      localization of MCP-1 in 16 cases of meningioma were studied using Northern blot 
      analysis and immunohistochemistry. Seven of 16 meningiomas expressed MCP-1 
      messenger ribonucleic acid and protein, and some degree of macrophage 
      infiltration was seen in all 16 meningiomas. There was a relationship between 
      MCP-1 expression and the degree of macrophage infiltration; MCP-1 was strongly 
      expressed in meningiomas with a high degree of macrophage infiltration. Sometimes 
      the meningioma was accompanied by perifocal edema; a correlation between 
      macrophage infiltration into brain tumors and perifocal edema has already been 
      reported. It was found that the degree of MCP-1 expression is not correlated with 
      the extent of perifocal edema. The authors' findings suggest that MCP-1 plays an 
      important role in macrophage infiltration into meningioma.
FAU - Sato, K
AU  - Sato K
AD  - Department of Neurosurgery, Kumamoto University Medical School, Japan.
FAU - Kuratsu, J
AU  - Kuratsu J
FAU - Takeshima, H
AU  - Takeshima H
FAU - Yoshimura, T
AU  - Yoshimura T
FAU - Ushio, Y
AU  - Ushio Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neurosurg
JT  - Journal of neurosurgery
JID - 0253357
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Cytokines)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blotting, Northern
MH  - Brain Neoplasms/genetics/*immunology/pathology
MH  - Chemokine CCL2
MH  - Chemotactic Factors/*analysis/genetics
MH  - Cytokines/*analysis
MH  - Edema/immunology
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Macrophages/*pathology
MH  - Male
MH  - Meningioma/genetics/*immunology/pathology
MH  - Middle Aged
MH  - RNA, Messenger/analysis
MH  - Tomography, X-Ray Computed
MH  - Tumor Cells, Cultured
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.3171/jns.1995.82.5.0874 [doi]
PST - ppublish
SO  - J Neurosurg. 1995 May;82(5):874-8. doi: 10.3171/jns.1995.82.5.0874.