PMID- 7714803
OWN - NLM
STAT- MEDLINE
DCOM- 19950517
LR  - 20211203
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 273
IP  - 1
DP  - 1995 Apr
TI  - Comparison of the effects of evening primrose oil and triglycerides containing 
      gamma-linolenic acid on nerve conduction and blood flow in diabetic rats.
PG  - 49-55
AB  - The aim was to ascertain whether the ability of evening primrose oil (EPO) 
      treatment to correct peripheral nerve dysfunction in streptozotocin-diabetic rats 
      depends on a gamma-linolenic acid (GLA)-containing triglyceride constituent, 
      di-linolein mono-gamma-linolenate (DLMG). A second objective was to investigate 
      whether the triglyceride conformation of GLA affects efficacy, using 
      tri-gamma-linolenate (TGLA), which is not present in EPO. Third, we examined the 
      actions of these omega-6 essential fatty acid-containing oils on sciatic nerve 
      blood flow to establish a common mechanism. After 6 weeks of diabetes, sciatic 
      motor nerve conduction velocity (NCV) was 21% reduced. EPO treatment caused 
      dose-dependent increases in NCV that reached asymptote within 7 days. DLMG and 
      TGLA, at doses matched for GLA content, had effects indistinguishable from those 
      of EPO. Sciatic blood flow, 47.2% reduced by diabetes, was partially normalized 
      by EPO, DLMG and TGLA. In contrast, sunflower oil (which does not contain GLA) 
      did not alter NCV or blood flow. The data therefore provide strong evidence that 
      DLMG is the active component of EPO and suggest that correction of nerve 
      dysfunction involves a vascular action. The precise triglyceride configuration of 
      GLA does not appear crucial to its effects in experimental diabetic neuropathy.
FAU - Dines, K C
AU  - Dines KC
AD  - Department of Biomedical Sciences, University of Aberdeen, Scotland, UK.
FAU - Cameron, N E
AU  - Cameron NE
FAU - Cotter, M A
AU  - Cotter MA
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Fatty Acids, Essential)
RN  - 0 (Linoleic Acids)
RN  - 0 (Plant Oils)
RN  - 0 (Triglycerides)
RN  - 3Q9L08K71N (evening primrose oil)
RN  - 5GRO578KLP (Flurbiprofen)
RN  - 5W494URQ81 (Streptozocin)
RN  - 78YC2MAX4O (gamma-Linolenic Acid)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Experimental/*physiopathology
MH  - Dietary Fats, Unsaturated/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Fatty Acids, Essential/*pharmacology
MH  - Flurbiprofen/pharmacology
MH  - Linoleic Acids
MH  - Male
MH  - Neural Conduction/*drug effects
MH  - Oenothera biennis
MH  - Plant Oils
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Regional Blood Flow/drug effects
MH  - Sciatic Nerve/blood supply/drug effects
MH  - Streptozocin
MH  - Triglycerides/*pharmacology
MH  - gamma-Linolenic Acid/*pharmacology
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1995 Apr;273(1):49-55.