PMID- 7716542
OWN - NLM
STAT- MEDLINE
DCOM- 19950518
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 268
IP  - 5209
DP  - 1995 Apr 21
TI  - Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I 
      receptors on T lymphocytes.
PG  - 403-5
AB  - Bacterial superantigens bind with high affinity to major histocompatibility 
      complex (MHC) class II antigens on antigen-presenting cells and with T cell 
      antigen receptor (TCR) beta chains on T lymphocytes, which results in the T cell 
      activation responsible for toxic shock syndrome and food poisoning. Many 
      cytotoxic T lymphocyte (CTL) clones were shown to have receptors for human 
      leukocyte antigen (HLA) class I molecules that inhibited superantigen-induced 
      cytotoxicity against appropriate class I-bearing target cells. One type of 
      inhibitory receptor, NKB1, was present on CD4+ and CD8+TCR alpha beta+ CTL clones 
      and blocked the killing of staphylococcal enterotoxin B (SEB)-coated targets 
      bearing certain polymorphic HLA-B molecules. Expression of HLA-A, -B, and -C 
      molecules on the SEB-coated targets also protected against cytolysis mediated by 
      many NKB1-negative T cell clones, suggesting the presence of additional 
      inhibitory MHC class I receptors. These HLA class I receptors may limit tissue 
      destruction and possibly autoimmunity caused by activated T lymphocytes.
FAU - Phillips, J H
AU  - Phillips JH
AD  - Department of Human Immunology, DNAX Research Institute of Molecular and Cellular 
      Biology, Palo Alto, CA 94304, USA.
FAU - Gumperz, J E
AU  - Gumperz JE
FAU - Parham, P
AU  - Parham P
FAU - Lanier, L L
AU  - Lanier LL
LA  - eng
GR  - AI22039/AI/NIAID NIH HHS/United States
GR  - GM07276/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Enterotoxins)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR3DL1)
RN  - 0 (Superantigens)
RN  - 39424-53-8 (enterotoxin B, staphylococcal)
SB  - IM
CIN - Science. 1995 Apr 21;268(5209):367-8. PMID: 7716537
MH  - Adult
MH  - *Cytotoxicity, Immunologic
MH  - Enterotoxins/immunology
MH  - HLA-A Antigens/immunology
MH  - HLA-B Antigens/immunology
MH  - HLA-C Antigens/immunology
MH  - Humans
MH  - Receptors, Antigen, T-Cell/*immunology
MH  - Receptors, Antigen, T-Cell, alpha-beta/immunology
MH  - Receptors, Immunologic/*immunology
MH  - Receptors, KIR
MH  - Receptors, KIR3DL1
MH  - Superantigens/*immunology
MH  - T-Lymphocytes, Cytotoxic/*immunology
MH  - Transfection
EDAT- 1995/04/21 00:00
MHDA- 1995/04/21 00:01
CRDT- 1995/04/21 00:00
PHST- 1995/04/21 00:00 [pubmed]
PHST- 1995/04/21 00:01 [medline]
PHST- 1995/04/21 00:00 [entrez]
AID - 10.1126/science.7716542 [doi]
PST - ppublish
SO  - Science. 1995 Apr 21;268(5209):403-5. doi: 10.1126/science.7716542.