PMID- 7719725
OWN - NLM
STAT- MEDLINE
DCOM- 19950525
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 670
IP  - 1
DP  - 1995 Jan 23
TI  - c-fos expression in the paraventricular nucleus of the hypothalamus following 
      intracerebroventricular infusions of neuropeptide Y.
PG  - 59-65
AB  - Intracerebroventricular (i.c.v.) infusions of neuropeptide Y (NPY) (2500 pmol) 
      induced c-fos protein in the paraventricular nucleus (PVN) of intact male rats 60 
      min later. The greatest expression was observed in the dorsal (parvicellular) 
      region of the PVN; there were intermediate levels in the lateral (magnocellular) 
      and lowest ones in the medial (parvicellular) regions. Allowing rats to eat 
      during the post-infusion interval did not modify this pattern of c-fos 
      expression. Depriving rats of food for either 24 or 48 h did not induce 
      recognisable expression of c-fos in the PVN, and allowing 24 h-deprived rats to 
      eat also had no effect on PVN c-fos. Plasma insulin was increased by i.c.v. NPY, 
      and raised still further in rats that were allowed to eat following NPY 
      infusions. However, plasma glucose was not altered by either treatment. 
      Food-deprived rats had low levels of insulin, but unaltered blood glucose, 
      compared to controls. These results show that NPY can induce c-fos expression in 
      both parvicellular and magnocellular areas of the PVN. The pattern of expression 
      within the PVN seems to differ from that induced by other peptides, such as 
      angiotensin II, vasopressin and corticotropin-releasing factor, suggesting that 
      distinct populations of neurons are activated by different peptides within the 
      complex structure of the PVN. Food deprivation does not induce c-fos expression 
      within the PVN, though other studies have shown that NPY levels and release are 
      both increased, so there is no simple relation between current energy state, 
      blood levels of either glucose or insulin and c-fos expression within the PVN.
FAU - Lambert, P D
AU  - Lambert PD
AD  - Department of Endocrinology, Royal Postgraduate Medical School, Hammersmith 
      Hospital, Cambridge, UK.
FAU - Phillips, P J
AU  - Phillips PJ
FAU - Wilding, J P
AU  - Wilding JP
FAU - Bloom, S R
AU  - Bloom SR
FAU - Herbert, J
AU  - Herbert J
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Proto-Oncogene Proteins c-fos)
SB  - IM
MH  - Animals
MH  - Blood Glucose
MH  - Eating
MH  - Gene Expression
MH  - Hypothalamus/*drug effects/physiology
MH  - Injections, Spinal
MH  - Insulin
MH  - Male
MH  - Neuropeptide Y/*pharmacology
MH  - Proto-Oncogene Proteins c-fos/*genetics/physiology
MH  - Rats
EDAT- 1995/01/23 00:00
MHDA- 1995/01/23 00:01
CRDT- 1995/01/23 00:00
PHST- 1995/01/23 00:00 [pubmed]
PHST- 1995/01/23 00:01 [medline]
PHST- 1995/01/23 00:00 [entrez]
AID - 0006-8993(94)01224-6 [pii]
AID - 10.1016/0006-8993(94)01224-6 [doi]
PST - ppublish
SO  - Brain Res. 1995 Jan 23;670(1):59-65. doi: 10.1016/0006-8993(94)01224-6.