PMID- 7722336
OWN - NLM
STAT- MEDLINE
DCOM- 19950524
LR  - 20071114
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 154
IP  - 9
DP  - 1995 May 1
TI  - Induction of experimental autoimmune sialoadenitis by immunization of PL/J mice 
      with carbonic anhydrase II.
PG  - 4865-73
AB  - Experimental autoimmune sialoadenitis was induced in PL/J (H-2u) mice by 
      intradermal immunization with human carbonic anhydrase II (CAII) and adjuvant 
      containing monophosphoryl lipid A and trehalose diorynomycolate. Mice immunized 
      with CAII showed a significant increase in the number and size of foci with 
      lymphocytic infiltration in the salivary gland compared with mice immunized with 
      adjuvant alone and untreated mice. In mice immunized with CAII, lymphocytic foci 
      were observed around intercalated and intralobular ducts in the salivary glands, 
      resulting in atrophy and replacement of acinar units. The epithelial cells of 
      salivary ducts adjacent to the lymphocytic foci showed both degenerative and 
      regenerative changes. Similar lymphocytic infiltrations were observed in the 
      pancreas and kidney of a few mice immunized with CAII. Among several mouse 
      strains with different H-2 haplotypes (p, q, r, s, and u), strains bearing H-2s 
      and H-2u were susceptible to CAII-induced sialoadenitis. These results indicate 
      that sialoadenitis induced by the immunization of CAII in mice may serve as a 
      disease model of Sjogren's syndrome and that CAII or its derived peptides in 
      association with the MHC may be one Ag recognized by an autoimmune response in 
      this syndrome.
FAU - Nishimori, I
AU  - Nishimori I
AD  - Eppley Cancer Institute, University of Nebraska Medical Center, Omaha 68198, USA.
FAU - Bratanova, T
AU  - Bratanova T
FAU - Toshkov, I
AU  - Toshkov I
FAU - Caffrey, T
AU  - Caffrey T
FAU - Mogaki, M
AU  - Mogaki M
FAU - Shibata, Y
AU  - Shibata Y
FAU - Hollingsworth, M A
AU  - Hollingsworth MA
LA  - eng
GR  - CA 36727/CA/NCI NIH HHS/United States
GR  - DK 46589/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (H-2 Antigens)
RN  - EC 4.2.1.1 (Carbonic Anhydrases)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/chemically induced/*immunology/pathology
MH  - Blotting, Western
MH  - Carbonic Anhydrases/*immunology
MH  - H-2 Antigens/genetics
MH  - Immunization
MH  - Mice
MH  - Mice, Inbred DBA
MH  - Mice, Inbred Strains
MH  - Radioimmunoassay
MH  - Sialadenitis/chemically induced/*immunology/pathology
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1995 May 1;154(9):4865-73.