PMID- 7722722
OWN - NLM
STAT- MEDLINE
DCOM- 19950524
LR  - 20190814
IS  - 0278-2391 (Print)
IS  - 0278-2391 (Linking)
VI  - 53
IP  - 5
DP  - 1995 May
TI  - Expression of matrix metalloproteinase-3 in stage I and II squamous cell 
      carcinoma of the oral cavity.
PG  - 530-4
AB  - PURPOSE: The object of this study was to evaluate the significance of matrix 
      metalloproteinase-3 (MMP-3) in tumor invasion and metastasis of early squamous 
      cell carcinoma (SCC) of the oral cavity. MATERIALS AND METHODS: Surgical 
      specimens from 65 patients with stage I and II SCC of the oral cavity were the 
      subjects of this study. Tissue specimens were fixed in formalin and embedded in 
      paraffin, and the sections were stained with monospecific antibodies against 
      human MMP-3 by the avidin-biotin-peroxidase complex method. RESULTS: Of the 65 
      patients, 30 (46.2%) tested positive for MMP-3. Immunoreactivity revealed the 
      expression of MMP-3 to be in the small cancer nests in the advancing front of 
      invasion, but not in normal oral epithelium. MMP-3 expression was positively 
      correlated with tumor size, depth of tumor invasion, diffuse invasive mode, and 
      the high incidence of lymph node metastasis. CONCLUSION: MMP-3-containing tumors 
      will invade adjacent normal tissues more aggressively, including lymphatic and 
      blood vessels. Therefore, the examination of MMP-3 expression in biopsy specimens 
      should provide information useful in predicting the malignant potential of early 
      SCC of the oral cavity.
FAU - Kusukawa, J
AU  - Kusukawa J
AD  - Department of Oral and Maxillofacial Surgery, Kurume University School of 
      Medicine, Japan.
FAU - Sasaguri, Y
AU  - Sasaguri Y
FAU - Morimatsu, M
AU  - Morimatsu M
FAU - Kameyama, T
AU  - Kameyama T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Oral Maxillofac Surg
JT  - Journal of oral and maxillofacial surgery : official journal of the American 
      Association of Oral and Maxillofacial Surgeons
JID - 8206428
RN  - 0 (Neoplasm Proteins)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*enzymology
MH  - Chi-Square Distribution
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Lymphatic Metastasis
MH  - Male
MH  - Matrix Metalloproteinase 3
MH  - Metalloendopeptidases/*biosynthesis
MH  - Middle Aged
MH  - Mouth Neoplasms/*enzymology/pathology
MH  - Neoplasm Invasiveness/physiopathology
MH  - Neoplasm Proteins/*biosynthesis
MH  - Neoplasm Staging
MH  - Prognosis
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 0278-2391(95)90065-9 [pii]
AID - 10.1016/0278-2391(95)90065-9 [doi]
PST - ppublish
SO  - J Oral Maxillofac Surg. 1995 May;53(5):530-4. doi: 10.1016/0278-2391(95)90065-9.