PMID- 7725601
OWN - NLM
STAT- MEDLINE
DCOM- 19950522
LR  - 20170214
IS  - 0300-9858 (Print)
IS  - 0300-9858 (Linking)
VI  - 32
IP  - 1
DP  - 1995 Jan
TI  - Local production of tumor necrosis factor-alpha in corynebacterial pulmonary 
      lesions in sheep.
PG  - 68-71
AB  - Corynebacterium pseudotuberculosis infection is a common cause of pyogranulomas 
      in ovine lungs and often occurs as a dual infection with lentiviruses. This 
      coinfection usually leads to the development of chronic pneumonia and cachexia 
      that is similar to the clinical syndrome seen in human beings with AIDS-related 
      pneumonias. Recent in vitro studies indicate that monokines such as tumor 
      necrosis factor-alpha (TNF alpha) are induced by C. pseudotuberculosis, 
      suggesting that TNF alpha is involved in the pathogenesis of corynebacterial 
      lesions in vivo. To substantiate in vitro observations concerning bacterial 
      induction of TNF alpha in ovine pulmonary macrophages, immunohistochemical 
      labeling techniques were used in combination with in situ hybridization to 
      identify TNF-producing cells in corynebacterial lesion sites in vivo. TNF alpha 
      message and translation product were found in macrophages comprising 
      pyogranulomas that were induced by naturally acquired and experimental pulmonary 
      C. pseudotuberculosis infections.
FAU - Ellis, J A
AU  - Ellis JA
AD  - Department of Veterinary Microbiology, WCVM, University of Saskatchewan, 
      Saskatoon, Canada.
FAU - Campos, M
AU  - Campos M
FAU - Snyder, M
AU  - Snyder M
FAU - Chelak, B
AU  - Chelak B
FAU - Haines, D M
AU  - Haines DM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Vet Pathol
JT  - Veterinary pathology
JID - 0312020
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Corynebacterium Infections/metabolism/microbiology/*veterinary
MH  - Corynebacterium pseudotuberculosis/isolation & purification/*physiology
MH  - Female
MH  - Immunohistochemistry
MH  - In Situ Hybridization/veterinary
MH  - Lung/metabolism/microbiology/pathology
MH  - Lung Diseases/metabolism/microbiology/*veterinary
MH  - Macrophages, Alveolar/chemistry/metabolism/pathology
MH  - Sheep
MH  - Sheep Diseases/*metabolism/microbiology/pathology
MH  - Tumor Necrosis Factor-alpha/analysis/*metabolism
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1177/030098589503200112 [doi]
PST - ppublish
SO  - Vet Pathol. 1995 Jan;32(1):68-71. doi: 10.1177/030098589503200112.