PMID- 7726645
OWN - NLM
STAT- MEDLINE
DCOM- 19950523
LR  - 20190904
IS  - 0090-4341 (Print)
IS  - 0090-4341 (Linking)
VI  - 28
IP  - 3
DP  - 1995 Apr
TI  - Dietary exposure of mink to carp from Saginaw Bay, Michigan. 1. Effects on 
      reproduction and survival, and the potential risks to wild mink populations.
PG  - 334-43
AB  - Carp (Cyprinus carpio) collected from Saginaw Bay, Michigan, containing 8.4 mg 
      total polychlorinated biphenyls (PCBs)/kg and 194 ng of 
      2,3,7,8-tetrachloro-dibenzo-p-dioxin equivalents (TEQs)/kg, were substituted for 
      marine fish at levels of 0, 10, 20, or 40% in the diets of adult ranch mink 
      (Mustela vison). The diets, containing 0.015, 0.72, 1.53, and 2.56 mg PCBs/kg 
      diet, or 1.03, 19.41, 40.02, and 80.76 ng TEQs/kg diet, respectively, were fed to 
      mink prior to and throughout the reproductive period to evaluate the effects of a 
      naturally-contaminated prey species on their survival and reproductive 
      performance. The total quantities of PCBs ingested by the mink fed 0, 10, 20, or 
      40% carp over the 85-day treatment period were 0.34, 13.2, 25.3, and 32.3 mg 
      PCBs/mink. respectively. The corresponding quantities of TEQs ingested by the 
      mink over the same treatment period were 23, 356, 661, and 1,019 ng TEQs/mink, 
      respectively. Consumption of feed by mink was inversely proportional to the PCB 
      and TEQ content of the diet. The diet containing Saginaw Bay carp caused impaired 
      reproduction and/or reduced survival of the kits. Compared to controls, body 
      weights of kits at birth were significantly reduced in the 20 and 40% carp 
      groups, and kit body weights and survival in the 10 and 20% carp groups were 
      significantly reduced at three and six weeks of age. The females fed 40% carp 
      whelped the fewest number of kits, all of which were stillborn or died within 24 
      hours. Lowest observable adverse effect levels (LOAEL) of 0.134 mg PCBs/kg body 
      weight/day or 3.6 ng TEQs/kg body weight/day for adult female mink were 
      determined. The potential effects of exposure of wild mink to contaminated Great 
      Lakes fish were assessed by calculating "maximum allowable daily intakes" and 
      "hazard indices" based on total concentrations of PCB residues in several species 
      of Great Lakes fish and mink toxicity data derived from the study.
FAU - Heaton, S N
AU  - Heaton SN
AD  - Department of Animal Science, Michigan State University, East Lansing 48824.
FAU - Bursian, S J
AU  - Bursian SJ
FAU - Giesy, J P
AU  - Giesy JP
FAU - Tillitt, D E
AU  - Tillitt DE
FAU - Render, J A
AU  - Render JA
FAU - Jones, P D
AU  - Jones PD
FAU - Verbrugge, D A
AU  - Verbrugge DA
FAU - Kubiak, T J
AU  - Kubiak TJ
FAU - Aulerich, R J
AU  - Aulerich RJ
LA  - eng
GR  - ES-04911/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Arch Environ Contam Toxicol
JT  - Archives of environmental contamination and toxicology
JID - 0357245
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Carps
MH  - Female
MH  - Foodborne Diseases/etiology/mortality/*veterinary
MH  - Male
MH  - Michigan
MH  - *Mink
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Polychlorinated Dibenzodioxins/*toxicity
MH  - Random Allocation
MH  - Reproduction/drug effects
MH  - Water Pollutants, Chemical/*toxicity
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
AID - 10.1007/BF00213111 [doi]
PST - ppublish
SO  - Arch Environ Contam Toxicol. 1995 Apr;28(3):334-43. doi: 10.1007/BF00213111.