PMID- 7729610
OWN - NLM
STAT- MEDLINE
DCOM- 19950531
LR  - 20221207
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 44
IP  - 5
DP  - 1995 May
TI  - DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous 
      DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry.
PG  - 527-30
AB  - The human leukocyte antigen (HLA) class II genotype 
      DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 has been identified as a marker strongly 
      predisposing to insulin-dependent diabetes mellitus (IDDM) in Caucasian 
      populations. Its frequency in control populations (1-3%) is still, however, 1 
      order of magnitude higher than the prevalence of IDDM, suggesting that its 
      penetrance can be modified by protective factors. In this study we searched for 
      such a factor in the DRB1 locus by studying DRB1*04 polymorphism in 174 European 
      Caucasian IDDM patients and 73 nondiabetic control subjects, all sharing the 
      HLA-DR3/DR4 phenotype. Significant protection was encoded by the DRB1*0403 
      allele, which was observed in 5 of 49 control subjects (10%) and none of 171 IDDM 
      patients (0%) with the DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype (RR = 
      0.02 [0.01-0.18], P < 0.0005). These data support the concept that protective HLA 
      class II genes can overrule the risk caused by HLA-DQ susceptibility dimers. They 
      also contribute to a possible strategy to screen for nondiabetic individuals with 
      increased genetic risk of developing IDDM.
FAU - Van der Auwera, B
AU  - Van der Auwera B
AD  - Department of Biochemistry, Vrije Universiteit Brussel, Belgium.
FAU - Van Waeyenberge, C
AU  - Van Waeyenberge C
FAU - Schuit, F
AU  - Schuit F
FAU - Heimberg, H
AU  - Heimberg H
FAU - Vandewalle, C
AU  - Vandewalle C
FAU - Gorus, F
AU  - Gorus F
FAU - Flament, J
AU  - Flament J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (DNA Probes)
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Base Sequence
MH  - DNA Probes/genetics
MH  - Diabetes Mellitus, Type 1/*genetics/*immunology/prevention & control
MH  - Female
MH  - Gene Frequency
MH  - Genetic Markers
MH  - Genotype
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - Molecular Sequence Data
MH  - Risk Factors
MH  - White People/genetics
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.2337/diab.44.5.527 [doi]
PST - ppublish
SO  - Diabetes. 1995 May;44(5):527-30. doi: 10.2337/diab.44.5.527.