PMID- 7732661
OWN - NLM
STAT- MEDLINE
DCOM- 19950601
LR  - 20191023
IS  - 0920-8569 (Print)
IS  - 0920-8569 (Linking)
VI  - 9
IP  - 2
DP  - 1995 Jan
TI  - Augmentation of c-fos and c-jun expression in transgenic mice carrying the human 
      T-cell leukemia virus type-I tax gene.
PG  - 161-70
AB  - To analyze the effect of human T-cell leukemia virus type I (HTLV-I) on cellular 
      gene expression and its relation to tumorigenesis, two lines of transgenic mice 
      carrying the long terminal repeat (LTR)-env-pX-LTR regions of the HTLV-I genome 
      were produced. The transgene was expressed in many organs, including the brain, 
      salivary gland, spleen, thymus, skin, muscle, and mammary gland. We found that 
      the expression of the c-fos and c-jun genes, but not of the lyn and c-myc genes, 
      was augmented 2- to 20-fold in histologically normal skin and muscle of these 
      mice. The augmentation was tissue specific, suggesting the involvement of a 
      cellular factor in the transgene action. In these mice, a three to seven times 
      higher incidence of tumors was seen as compared with the control mice. These 
      tumors included mesenchymal tumors, such as fibrosarcoma, neurofibroma, and 
      lipoma, and adenocarcinomas of the mammary gland, salivary gland, and lung. The 
      c-fos and c-jun genes were also activated in these tumors. The possible roles of 
      elevated c-fos and c-jun gene expression in tumorigensis are discussed.
FAU - Iwakura, Y
AU  - Iwakura Y
AD  - Institute of Medical Science, University of Tokyo, Japan.
FAU - Tosu, M
AU  - Tosu M
FAU - Yoshida, E
AU  - Yoshida E
FAU - Saijo, S
AU  - Saijo S
FAU - Nakayama-Yamada, J
AU  - Nakayama-Yamada J
FAU - Itagaki, K
AU  - Itagaki K
FAU - Asano, M
AU  - Asano M
FAU - Siomi, H
AU  - Siomi H
FAU - Hatanaka, M
AU  - Hatanaka M
FAU - Takeda, T
AU  - Takeda T
AU  - et al.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Virus Genes
JT  - Virus genes
JID - 8803967
SB  - IM
GS  - c-fos
GS  - c-jun
GS  - c-myc
GS  - lyn
GS  - tax
MH  - Animals
MH  - Female
MH  - *Gene Expression Regulation, Viral
MH  - Genes, env
MH  - *Genes, fos
MH  - *Genes, jun
MH  - *Genes, pX
MH  - Human T-lymphotropic virus 1/*genetics
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Transgenic
MH  - Neoplasms, Experimental/genetics/virology
MH  - Repetitive Sequences, Nucleic Acid/genetics
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1007/BF01702659 [doi]
PST - ppublish
SO  - Virus Genes. 1995 Jan;9(2):161-70. doi: 10.1007/BF01702659.