PMID- 7733001
OWN - NLM
STAT- MEDLINE
DCOM- 19950601
LR  - 20220408
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 75
IP  - 14
DP  - 1995 May 1
TI  - Results of atrioventricular synchronous pacing with optimized delay in patients 
      with severe congestive heart failure.
PG  - 919-23
AB  - To verify that atrioventricular (AV) synchronous pacing (DDD) with short AV delay 
      improves the condition of patients with severe congestive heart failure, we 
      implanted DDD pacemakers in 10 patients with severe heart failure (New York Heart 
      Association [NYHA] class III to IV). One day after pacemaker implantation, the AV 
      delay was optimized by Doppler echocardiographic measurements over the aortic 
      outflow tract. Patients were evaluated regarding NYHA class, stroke volume, 
      cardiac output, ejection fraction, and quality of life at 1, 3, and 6 months 
      after pacemaker implantation. Although the optimized AV delay was associated with 
      short-term improvement in stroke volume and cardiac output (baseline stroke 
      volume = 22 +/- 7 ml, day 1 = 28 +/- 12 ml; p = 0.03: baseline cardiac output = 
      1.9 +/- 0.6 L/min, day 1 = 2.2 +/- 1.1 L/min; p = 0.10), the mean stroke volume, 
      cardiac output, NYHA class, and ejection fraction did not change significantly 
      after 1, 3, and 6 months of pacing compared with baseline values. Three patients 
      improved in NYHA class during the follow-up. A consistent improvement in stroke 
      volume, cardiac output, NYHA class, and ejection fraction was observed in only 1 
      patient. In conclusion, we found no beneficial effects of AV-synchronous pacing 
      with optimized AV delay in patients with severe heart failure.
FAU - Linde, C
AU  - Linde C
AD  - Department of Cardiology, Karolinska Hospital, Stockholm, Sweden.
FAU - Gadler, F
AU  - Gadler F
FAU - Edner, M
AU  - Edner M
FAU - Nordlander, R
AU  - Nordlander R
FAU - Rosenqvist, M
AU  - Rosenqvist M
FAU - Ryden, L
AU  - Ryden L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Adult
MH  - Aged
MH  - Atrioventricular Node
MH  - Cardiac Output
MH  - Cardiac Pacing, Artificial/*methods
MH  - Echocardiography, Doppler
MH  - Evaluation Studies as Topic
MH  - Female
MH  - Heart Failure/classification/diagnostic imaging/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pacemaker, Artificial
MH  - Quality of Life
MH  - Treatment Outcome
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - S0002914999806870 [pii]
AID - 10.1016/s0002-9149(99)80687-0 [doi]
PST - ppublish
SO  - Am J Cardiol. 1995 May 1;75(14):919-23. doi: 10.1016/s0002-9149(99)80687-0.