PMID- 7735209
OWN - NLM
STAT- MEDLINE
DCOM- 19950608
LR  - 20190719
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 17
IP  - 12
DP  - 1994 Dec
TI  - Isotopic fractionation of isopropylantipyrine and its deuterated analogues by 
      capillary gas chromatography.
PG  - 1635-9
AB  - Isotopic fractionation of isopropylantipyrine (IPA) and its deuterated analogues 
      was examined by gas chromatography (GC) using capillary column. The separation of 
      IPA and seven kinds of deuterated IPAs were proportional to the number of labeled 
      deuterium atoms and inversely to the temperature of the column oven. The 
      resolution coefficient between IPA and IPA-3-C2H3-4-(C2H3)2 (IPA-2H-7) was 1.46 
      at 200 degrees C for column temperature. The present isotopic fractionation 
      procedure was applied to the isotope dilution analysis of IPA. Measurement of the 
      sample prepared by the addition of a known amount of IPA and IPA-2H-7 to the 
      control plasma of rabbit allowed observation of a linear relationship between 
      peak area ratio and added amount ratio. The correlation coefficient obtained by 
      regression analysis was 1.000. The present method was also applied to determine 
      the plasma level of IPA in rabbit after oral administration.
FAU - Goromaru, T
AU  - Goromaru T
AD  - Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan.
FAU - Maeda, H
AU  - Maeda H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - AR09D82C7G (Deuterium)
RN  - OED8FV75PY (propyphenazone)
RN  - T3CHA1B51H (Antipyrine)
SB  - IM
MH  - Animals
MH  - Antipyrine/*analogs & derivatives/blood/pharmacokinetics
MH  - Chromatography, Gas/*methods
MH  - Deuterium
MH  - Isotope Labeling
MH  - Male
MH  - Rabbits
MH  - Radioisotope Dilution Technique
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - 10.1248/bpb.17.1635 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 1994 Dec;17(12):1635-9. doi: 10.1248/bpb.17.1635.