PMID- 7735624
OWN - NLM
STAT- MEDLINE
DCOM- 19950607
LR  - 20220316
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 151
IP  - 5
DP  - 1995 May
TI  - Increased interleukin-1 and interleukin-6 serum concentrations in severe primary 
      pulmonary hypertension.
PG  - 1628-31
AB  - Primary pulmonary hypertension (PPH) is characterized by the proliferation of 
      smooth-muscle cells, fibroblasts, and endothelial cells in the walls of small 
      pulmonary arteries. In order to evaluate a role for proinflammatory cytokines in 
      this process, we studied the concentration of interleukin-1 beta (IL-1 beta), 
      IL-6, and tumor necrosis factor-alpha (TNF alpha) in the serum of 29 patients 
      with severe PPH referred to our center for lung transplantation. Results were 
      compared with those obtained in 15 normal controls and nine patients with 
      pulmonary hypertension secondary to chronic obstructive pulmonary disease 
      (COPD-PH). TNF alpha serum levels were within the normal range in each group. 
      This contrasted with increased IL-1 beta serum levels in severe PPH (118 +/- 36 
      pg/ml, mean +/- SEM) as compared with controls (3 +/- 1 pg/ml, p < 0.001) or 
      COPD-PH patients (3 +/- 1 pg/ml, p < 0.001). IL-6 serum concentrations were also 
      higher in severe PPH (66 +/- 20 pg/ml) than in controls (14 +/- 6 pg/ml, p < 
      0.01). This study demonstrates increased serum levels of IL-1 beta and IL-6 in 
      severe PPH, and suggests a role for proinflammatory cytokines in PPH.
FAU - Humbert, M
AU  - Humbert M
AD  - Laboratoire d'Immunopathologie et d'Immunologie Virale, INSERM U131, Clamart, 
      France.
FAU - Monti, G
AU  - Monti G
FAU - Brenot, F
AU  - Brenot F
FAU - Sitbon, O
AU  - Sitbon O
FAU - Portier, A
AU  - Portier A
FAU - Grangeot-Keros, L
AU  - Grangeot-Keros L
FAU - Duroux, P
AU  - Duroux P
FAU - Galanaud, P
AU  - Galanaud P
FAU - Simonneau, G
AU  - Simonneau G
FAU - Emilie, D
AU  - Emilie D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/*blood/etiology
MH  - Interleukin-1/*blood
MH  - Interleukin-6/*blood
MH  - Lung Diseases, Obstructive/complications
MH  - Male
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.1164/ajrccm.151.5.7735624 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 1995 May;151(5):1628-31. doi: 
      10.1164/ajrccm.151.5.7735624.