PMID- 7736386
OWN - NLM
STAT- MEDLINE
DCOM- 19950608
LR  - 20190620
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 75
IP  - 10
DP  - 1995 May 15
TI  - Hepatic arterial infusion of recombinant platelet factor-4 suppresses metastases 
      to the lungs from tumors implanted into the livers of rabbits.
PG  - 2435-41
AB  - BACKGROUND: This study evaluated the toxicity (Part I) and antitumor effects 
      (Part II) associated with hepatic arterial infusion of recombinant platelet 
      factor-4 (rPF4), an antiangiogenic protein. METHODS: Healthy rabbits (Part I) and 
      rabbits with tumors implanted in their livers (Part II) received saline or rPF4 
      via hepatic arterial infusion. Three saline-receiving and four rPF4-receiving 
      animals died 2-3 days postinfusion from gastroduodenal thromboembolism. The 
      remaining animals were necropsied 3, 7, 10, or 14 days postinfusion. Blood 
      analyses and hepatic angiography were performed before infusion and at the time 
      of sacrifice. RESULTS: In Part I, focal coagulation necrosis of the hepatic 
      parenchyma was observed in 1 of 11 rabbits that received saline and in 6 of 10 
      that received rPF4. In Part II, hepatic arterial infusion of rPF4 had no effect 
      on growth of the implanted liver tumors. However, the protein significantly 
      reduced the incidence of lung metastasis. CONCLUSIONS: Intraarterial infusion of 
      rPF4 significantly reduced the incidence of lung metastasis. Nonheparin systemic 
      anticoagulation may be needed during catheterization and infusion procedures to 
      prevent thromboemboli.
FAU - Yoshimitsu, K
AU  - Yoshimitsu K
AD  - Department of Diagnostic Radiology, University of Texas M.D. Anderson Cancer 
      Center, Houston 77030, USA.
FAU - Wright, K C
AU  - Wright KC
FAU - Wallace, S
AU  - Wallace S
FAU - Charnsangavej, C
AU  - Charnsangavej C
FAU - Mavligit, G M
AU  - Mavligit GM
LA  - eng
GR  - CA-16672/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (Recombinant Proteins)
RN  - 37270-94-3 (Platelet Factor 4)
SB  - IM
MH  - Animals
MH  - Arteries
MH  - Duodenum/blood supply
MH  - Hepatic Artery
MH  - Infusions, Intra-Arterial
MH  - Liver/drug effects/pathology
MH  - Liver Neoplasms, Experimental/*pathology
MH  - Lung Neoplasms/*prevention & control/*secondary
MH  - Necrosis
MH  - Neoplasm Transplantation
MH  - Platelet Factor 4/administration & dosage/adverse effects/*therapeutic use
MH  - Rabbits
MH  - Recombinant Proteins
MH  - Stomach/blood supply
MH  - Thromboembolism/chemically induced
EDAT- 1995/05/15 00:00
MHDA- 1995/05/15 00:01
CRDT- 1995/05/15 00:00
PHST- 1995/05/15 00:00 [pubmed]
PHST- 1995/05/15 00:01 [medline]
PHST- 1995/05/15 00:00 [entrez]
AID - 10.1002/1097-0142(19950515)75:10<2435::aid-cncr2820751008>3.0.co;2-l [doi]
PST - ppublish
SO  - Cancer. 1995 May 15;75(10):2435-41. doi: 
      10.1002/1097-0142(19950515)75:10<2435::aid-cncr2820751008>3.0.co;2-l.