PMID- 7737225
OWN - NLM
STAT- MEDLINE
DCOM- 19950608
LR  - 20190512
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 16
IP  - 1
DP  - 1995 Jan
TI  - The dispersion of repolarization in patients with ventricular tachycardia. A 
      study using simultaneous monophasic action potential recordings from two sites in 
      the right ventricle.
PG  - 68-76
AB  - The role of increased dispersion of repolarization in the genesis of torsade de 
      pointes and ventricular fibrillation has been well recognized generally, but not 
      in the genesis of monomorphic ventricular tachycardia (VT). Monophasic action 
      potentials (MAP) were therefore recorded simultaneously from the right 
      ventricular (RV) apex (RVA) and outflow tract (RVOT) during sinus rhythm, RV 
      pacing and programmed extra stimulation (PES) in 24 patients with VT. The 
      activation time (AT), MAP duration at 90% repolarization (MAPd), and 
      repolarization time (RT) were measured and their dispersions, defined as the 
      differences in these parameters between RVA and RVOT, were calculated. During 
      sinus rhythm and RV pacing, the dispersions of AT, MAPd and RT (dispersions) were 
      significantly larger in the 17 patients with a VT induced than in those without. 
      During PES, the dispersions were further augmented in the S2 beats in the seven 
      patients with a sustained VT induced, the maximal dispersion of RT being 85 +/- 
      22 ms. Both the dispersion of AT and that of MAPd contributed to the dispersion 
      of RT. In both of our two patients with a sustained VT induced during MAP 
      recording, a marked increase in dispersions of RT (140 and 190 ms, respectively) 
      was observed immediately before the initiation of the VT. A link between the 
      dispersions and the inducibility of a monomorphic VT was found in our patients, 
      which suggests that the increased dispersions play an important role in the 
      genesis of a monomorphic VT.
FAU - Yuan, S
AU  - Yuan S
AD  - Department of Cardiology, University Hospital, Lund, Sweden.
FAU - Wohlfart, B
AU  - Wohlfart B
FAU - Olsson, S B
AU  - Olsson SB
FAU - Blomstrom-Lundqvist, C
AU  - Blomstrom-Lundqvist C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
MH  - Action Potentials/*physiology
MH  - Adult
MH  - Aged
MH  - Cardiac Pacing, Artificial
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Tachycardia, Ventricular/*physiopathology
MH  - Ventricular Function, Right
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1093/eurheartj/16.1.68 [doi]
PST - ppublish
SO  - Eur Heart J. 1995 Jan;16(1):68-76. doi: 10.1093/eurheartj/16.1.68.