PMID- 7737285
OWN - NLM
STAT- MEDLINE
DCOM- 19950607
LR  - 20061115
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 25
IP  - 4
DP  - 1995 Apr
TI  - Interleukin-10 differentially regulates cytokine inhibitor and chemokine release 
      from blood mononuclear cells and fibroblasts.
PG  - 1129-32
AB  - In this study we have examined the effects of interleukin-10 (IL-10) on blood 
      mononuclear cells (MNC) and on skin as well as on synovial fibroblasts. In 
      unstimulated MNC, we found that IL-10 is a potent stimulator of interleukin-1 
      receptor antagonist (IL-1ra) and monocyte chemoattractant protein-1 (MCP-1) 
      production and an inhibitor of IL-8 release. In cells exposed to IL-1 beta, it 
      also moderately stimulated IL-1ra production and release of soluble tumor 
      necrosis factor receptor p75 (sTNF-R p75) and inhibited IL-8 and MCP-1 
      production. In addition, we have evidence that the biological effects of IL-10 
      are not restricted to hematopoietic cells. IL-10 stimulated sTNF-R p55 
      dose-dependently and inhibited MCP-1 release from IL-1 beta-activated 
      fibroblasts, whereas IL-8 production was not affected. Taken together, these 
      findings identify novel biological actions of IL-10 on blood mononuclear and 
      connective tissue cells which support its regulatory functions as a suppressor of 
      inflammatory processes.
FAU - Seitz, M
AU  - Seitz M
AD  - Division of Rheumatology, University Hospital, Bern, Switzerland.
FAU - Loetscher, P
AU  - Loetscher P
FAU - Dewald, B
AU  - Dewald B
FAU - Towbin, H
AU  - Towbin H
FAU - Gallati, H
AU  - Gallati H
FAU - Baggiolini, M
AU  - Baggiolini M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-8)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Cells, Cultured
MH  - Chemokine CCL2
MH  - Chemotactic Factors/*biosynthesis
MH  - Fibroblasts/immunology/metabolism
MH  - Humans
MH  - Interleukin-1/*biosynthesis
MH  - Interleukin-10/*pharmacology
MH  - Interleukin-8/*antagonists & inhibitors
MH  - Leukocytes, Mononuclear/drug effects/immunology/*metabolism
MH  - Receptors, Tumor Necrosis Factor/*biosynthesis
MH  - Skin/metabolism
MH  - Up-Regulation
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
AID - 10.1002/eji.1830250443 [doi]
PST - ppublish
SO  - Eur J Immunol. 1995 Apr;25(4):1129-32. doi: 10.1002/eji.1830250443.