PMID- 7737326
OWN - NLM
STAT- MEDLINE
DCOM- 19950608
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 273
IP  - 3
DP  - 1995 Feb 6
TI  - Effects of 5-HT receptor antagonists on morphine-induced tolerance in mice.
PG  - 203-7
AB  - The effect of 5-HT receptor antagonists on tolerance to morphine antinociception 
      was studied in mice. Slow release morphine suspension was injected subcutaneously 
      (s.c.) in order to produce tolerance. When different doses of morphine (3, 6 and 
      9 mg/kg) were administered on the 4th day after injection of slow-release 
      morphine suspension, tolerance to the test doses of morphine was observed. The 
      tolerance obtained was decreased by pretreatment with the non-selective 5-HT 
      receptor antagonist methysergide (1 and 2 mg/kg) or the 5-HT2 receptor antagonist 
      ritanserin (1 and 2 mg/kg). When the 5-HT receptor antagonists were used on the 
      2nd and 3rd day after injection of slow-release morphine suspension or on the 4th 
      day (60 min before last dose of morphine), a maximum reduction in morphine 
      tolerance was observed on the 3rd day. Pretreatment of animals with metergoline 
      (1 and 2 mg/kg) or mianserin (1 and 2 mg/kg) also decreased the tolerance to 
      morphine. It may be concluded that at least a 5-HT2 receptor mechanism is 
      involved in tolerance to morphine antinociception.
FAU - Zarrindast, M R
AU  - Zarrindast MR
AD  - Department of Pharmacology, School of Medicine, Tehran University of Medical 
      Sciences, Iran.
FAU - Sajedian, M
AU  - Sajedian M
FAU - Rezayat, M
AU  - Rezayat M
FAU - Ghazi-Khansari, M
AU  - Ghazi-Khansari M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Analgesics)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Serotonin Antagonists)
RN  - 145TFV465S (Ritanserin)
RN  - 1501393LY5 (Metergoline)
RN  - 250PJI13LM (Mianserin)
RN  - 76I7G6D29C (Morphine)
RN  - XZA9HY6Z98 (Methysergide)
SB  - IM
MH  - Analgesics/administration & dosage/*pharmacology
MH  - Animals
MH  - Delayed-Action Preparations
MH  - Drug Tolerance
MH  - Injections, Subcutaneous
MH  - Male
MH  - Metergoline/pharmacology
MH  - Methysergide/pharmacology
MH  - Mianserin/pharmacology
MH  - Mice
MH  - Morphine/administration & dosage/*pharmacology
MH  - Pain Measurement/drug effects
MH  - Ritanserin/pharmacology
MH  - Serotonin Antagonists/*pharmacology
EDAT- 1995/02/06 00:00
MHDA- 1995/02/06 00:01
CRDT- 1995/02/06 00:00
PHST- 1995/02/06 00:00 [pubmed]
PHST- 1995/02/06 00:01 [medline]
PHST- 1995/02/06 00:00 [entrez]
AID - 001429999400638N [pii]
AID - 10.1016/0014-2999(94)00638-n [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1995 Feb 6;273(3):203-7. doi: 10.1016/0014-2999(94)00638-n.