PMID- 7737336
OWN - NLM
STAT- MEDLINE
DCOM- 19950608
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 273
IP  - 3
DP  - 1995 Feb 6
TI  - Antagonists of the metabotropic glutamate receptor do not prevent induction of 
      long-term potentiation in the dentate gyrus of rats.
PG  - 291-4
AB  - The effects of two competitive metabotropic glutamate (mGlu) receptor 
      antagonists, (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) and 
      (S)-4-carboxylphenylglycine (4CPG), were studied on long-term potentiation in the 
      dentate gyrus of rats under urethane anaesthesia. Intracerebroventricular 
      (i.c.v.) injection of MCPG or 4CPG 30 min prior to tetanic stimulation of the 
      perforant path in rats did not affect the induction of long-term potentiation 
      measured by extracellular recording. As a control, i.c.v. injections of the NMDA 
      receptor antagonist, dl(-)-2-amino-5-phosphonopentanoic (dl-AP5), effectively 
      blocked long-term potentiation. These results suggest that the mGlu receptor 
      subtype blocked by MCPG and 4CPG is not involved in long-term potentiation in the 
      dentate gyrus.
FAU - Bordi, F
AU  - Bordi F
AD  - Glaxo Research Laboratories, Verona, Italy.
FAU - Ugolini, A
AU  - Ugolini A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Benzoates)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 146669-29-6 (alpha-methyl-4-carboxyphenylglycine)
RN  - 7292-81-1 (4-carboxyphenylglycine)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/pharmacology
MH  - Animals
MH  - Benzoates/administration & dosage/pharmacology
MH  - Evoked Potentials/drug effects
MH  - Glycine/administration & dosage/analogs & derivatives/pharmacology
MH  - Hippocampus/*drug effects
MH  - In Vitro Techniques
MH  - Injections, Intraventricular
MH  - Long-Term Potentiation/*drug effects
MH  - Male
MH  - Neural Pathways/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Metabotropic Glutamate/*antagonists & inhibitors
EDAT- 1995/02/06 00:00
MHDA- 1995/02/06 00:01
CRDT- 1995/02/06 00:00
PHST- 1995/02/06 00:00 [pubmed]
PHST- 1995/02/06 00:01 [medline]
PHST- 1995/02/06 00:00 [entrez]
AID - 001429999400756W [pii]
AID - 10.1016/0014-2999(94)00756-w [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1995 Feb 6;273(3):291-4. doi: 10.1016/0014-2999(94)00756-w.