PMID- 7738367
OWN - NLM
STAT- MEDLINE
DCOM- 19950602
LR  - 20190723
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 104
IP  - 5
DP  - 1995 May
TI  - Comparative genetic association of human leukocyte antigen class II and tumor 
      necrosis factor-alpha with dermatitis herpetiformis.
PG  - 856-8
AB  - Dermatitis herpetiformis is a chronic subepidermal vesicular autoimmune skin 
      disease characterized by a strong association with the human leukocyte antigen 
      A1-B8-DR3-DQ2 haplotype. Although the strongest major histocompatibility complex 
      association has been shown to be with the DQw2 (DQB1*0201/DQA1*0501) heterodimer, 
      recent evidence has suggested that there may be up to three susceptibility loci 
      within the major histocompatibility complex. Tumor necrosis factor-alpha 
      (TNF-alpha) is a cytokine with a broad range of proinflammatory, 
      immunomodulating, and catabolic activities. We have recently described the first 
      known polymorphism in the human TNF-alpha gene, which is biallelic and lies in 
      the promoter region. The rare allele, TNF2, is in strong linkage disequilibrium 
      with the human leukocyte antigen A1-B8-DR3-DQ2 haplotype. We therefore examined 
      TNF-alpha genotypes in patients with dermatitis herpetiformis and controls and 
      compared the association with that of the class II alleles. Although TNF2 is 
      strongly associated with dermatitis herpetiformis, this was weaker than the 
      association with the class II loci, with DQw2 (DQB1*0201/DQA1*0501) showing the 
      strongest disease association. Of the four patients negative for this marker, 
      only one carried the TNF2 allele. These results indicate that TNF2 is not a major 
      disease susceptibility marker, although our results do not exclude a minor role.
FAU - Wilson, A G
AU  - Wilson AG
AD  - University Department of Medicine, Royal Hallamshire Hospital, University of 
      Sheffield, England.
FAU - Clay, F E
AU  - Clay FE
FAU - Crane, A M
AU  - Crane AM
FAU - Cork, M J
AU  - Cork MJ
FAU - Duff, G W
AU  - Duff GW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Alleles
MH  - Base Sequence
MH  - Dermatitis Herpetiformis/*genetics
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - Heterozygote
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Homozygote
MH  - Humans
MH  - Leukocytes/*immunology
MH  - Molecular Sequence Data
MH  - Polymorphism, Genetic
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - S0022-202X(15)42143-8 [pii]
AID - 10.1111/1523-1747.ep12607031 [doi]
PST - ppublish
SO  - J Invest Dermatol. 1995 May;104(5):856-8. doi: 10.1111/1523-1747.ep12607031.