PMID- 7738429
OWN - NLM
STAT- MEDLINE
DCOM- 19950602
LR  - 20061115
IS  - 0022-2143 (Print)
IS  - 0022-2143 (Linking)
VI  - 125
IP  - 5
DP  - 1995 May
TI  - Value of antibody level in diagnosing anhydride-induced immunologic respiratory 
      disease.
PG  - 650-3
AB  - The objective of this study was to determine whether immunologic 
      anhydride-induced respiratory disease could be predicted on the basis of the 
      level of specific immunoglobulin E (IgE) or immunoglobulin G (IgG) antibody. 
      Eight-one anhydride-exposed employees in one plant were studied. Fourteen had 
      disease and 67 did not. Immunologic studies were performed by enzyme-linked 
      immunosorbent assay and expressed as titers. When optimal discriminant analysis 
      was used, IgE < 1:5 and IgG < or = 1:10 were found to be the optimal titers for 
      separating employees with and without immunologic respiratory disease caused by 
      anhydrides. When IgG < or = 1:10 was used, 62 of 81 workers were correctly 
      classified; the sensitivity was 100%, the positive predictive value was 45%, the 
      specificity was 75%, and the negative predictive value was 100%. When IgE < 1:5 
      was used, 73 of 81 workers were correctly classified; the sensitivity was 86%, 
      the positive predictive value was 67%, the specificity was 91%, and the negative 
      predictive value was 97%. In conclusion, anhydride disease status can be 
      predicted on the basis of specific IgG or IgE antibody level.
FAU - Grammer, L C
AU  - Grammer LC
AD  - Department of Medicine, Northwestern University Medical School, Chicago, IL 
      60611, USA.
FAU - Shaughnessy, M A
AU  - Shaughnessy MA
FAU - Hogan, M B
AU  - Hogan MB
FAU - Berggruen, S M
AU  - Berggruen SM
FAU - Watkins, D M
AU  - Watkins DM
FAU - Yarnold, P R
AU  - Yarnold PR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Lab Clin Med
JT  - The Journal of laboratory and clinical medicine
JID - 0375375
RN  - 0 (Antibodies)
RN  - 0 (Epoxy Resins)
RN  - 0 (Phthalic Anhydrides)
RN  - 37226-48-5 (araldite)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antibodies/*analysis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Epoxy Resins/*adverse effects
MH  - Humans
MH  - Immunoglobulin E/analysis
MH  - *Immunologic Tests
MH  - Occupational Diseases/chemically induced/diagnosis/immunology
MH  - Phthalic Anhydrides/*adverse effects
MH  - Predictive Value of Tests
MH  - Respiratory Hypersensitivity/*chemically induced/diagnosis/*immunology
MH  - Sensitivity and Specificity
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
PST - ppublish
SO  - J Lab Clin Med. 1995 May;125(5):650-3.